Occupational health is an important construction part of Healthy China Initiative. Because of the particularity of the working environment, archivists may have many occupational health problems, so it is very necessary to understand the current situation and influencing factors of occupational health of archivists. This paper takes the eye irritation symptoms as an example. Questionnaires are distributed to archivists all over the country to collect data, and chi-square test and multivariate logistic regression are used to analyze the influencing factors of archivists' eye irritation symptoms. The results show that the prevalence of eye irritation symptoms among archivists is 41.3%. There are significant differences among archivists with eye irritation symptoms, such as the length of working years, the number of times of contacting paper archives, whether the working environment is humid, the ventilation mode and time of the warehouse, whether there is irritating chemical odor in the workplace, whether there is musty smell and pests, the length of working in front of the computer, and the number of times of using printers and copiers (P<0.05). Multivariate logistic regression analysis shows that the presence of harsh chemical odors in the workplace is the most associated with the risk of eye irritation symptoms. High frequency of contact with paper files, long time of computer use, and frequent use of printers and copiers are also risk factors of eye irritation. Protective factors include high education, warehouse power and natural ventilation, etc. There are many risk factors in the working environment that cause eye irritation symptoms of archivists, and these risk factors can also lead to other health problems for archivists. It is necessary for archives managers and frontline archivists to pay attention to and formulate targeted prevention and treatment strategies to protect the occupational health of archivists.