Abstract: 【Purpose/significance】This study aims to explore the application situation and collaboration strategy of Mixed Methods Re?
search in LIS, deepen the understanding of the applicable scenarios of MMR, and promote the rationalization and effectiveness of strat? egy use in research design【. Method/process】An analysis of mixed methods articles published in four representative LIS research jour? nals from 2012 to 2021, revealed the application context and strategies for collaboration of mixed method【. Result/conclusion】There are three situations mixed methods in library and information science research: bridging the technical limitations of single method, en? suring the integrity and continuity of research and strengthening the support of research conclusions. Besides, this study also illustrates six strategies for qualitative and quantitative collaboration: supplementary explanation; construction guidance; test and promotion; quantitative extension; joint guarantee and parallel coordination. Finally, we prospect the trend of MMR.【Innovation/limitation】The research conclusions are helpful for researchers to better understand how to design and apply mixed methods research, improve the quality of LIS research, and enhance the scientificity and rigor of mixed method research. We only choose 4 journals as example, but we will broaden the scope of our study in the future.