Chinese Journal of Radiation Oncology

中华放射肿瘤学杂志

中华放射肿瘤学杂志

Office

Journal

Archive

RSS

Download

Instruction

Template

Quick Search

Advanced Search

Chinese Journal of Radiation Oncology

	2020 Vol.29 Issue.7 Published 2020-07-15

	Head and Neck Tumors Abdominal Tumors Thoracic Tumors Special Feature Review Articles Physics · Biology · Technique

Special Feature

	495	Research progress on accelerator-based stereotactic body radiotherapy
		Cheng Guanghui, Zhao Hongfu, Liu Ying
		Stereotactic body radiotherapy (SBRT) has become an important radiotherapy technology. In recent years, with the continuous improvement of the mechanical properties of the linear accelerator (LINAC), LINAC-based SBRT is gradually emerging. In this article, the history, technological progress, radiation physics, clinical application of LINAC-based SBRT were elaborated, aiming to promote the development of LINAC-based SBRT.
		2020 Vol. 29 (7): 495-501 [Abstract] ( 176 ) [HTML 1KB] [ PDF 982KB] ( 0 )

Head and Neck Tumors

	502	Effects of different combinations of comprehensive treatment on survival of patients with locally advanced head and neck squamous cell carcinoma:post-hoc analysis of a phase Ⅲ randomized controlled clinical trial
		Wang Kai, Qu Yuan, Yi Junlin, Chen Xuesong, Wang Xiaolei, Liu Shaoyan, Xu Zhengang, ZhangShiping, Wu Runye, Zhang Ye, Li Suyan, Luo Jingwei, Xiao Jianping, Gao Li, Xu Guozhen, Li Yexiong, Huang Xiaodong
		Objective To compare the effects of comprehensive treatment with different combinations of radiotherapy, chemotherapy and surgery on the survival of patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Methods From September 2002 to May 2012, 222 patients were enrolled in a randomized controlled clinical trial to compare the clinical efficacy between preoperative radiotherapy and preoperative concurrent chemoradiotherapy. The chemotherapy was performed at the beginning of the radiotherapy, with cisplatin 30 mg/m² every week. Conventional radiotherapy or intensity-modulated radiotherapy (IMRT) was adopted. Clinical efficacy was evaluated during radiotherapy to 50Gy in all patients. Whether surgery or original treatment regime was given was determined according to the clinical efficacy. The survival of different therapeutic methods was analyzed by Kaplan-Meier method. ResultsThe median follow-up time was 59 months (7-139 months). All patients were divided into four groups:radiotherapy group (R group,n=84), concurrent chemo-radiotherapy group (R+C group, n=67), preoperative radiotherapy group (R+S group, n=34) and preoperative concurrent chemoradiotherapy group (R+C+S group, n=37). The 5-year overall survival rates were 32%, 44%, 51%, and 52%, respectively (R+C+S group vs. R group, P=0.047). The 5-year progression-free survival rates were 34%, 48%, 49%, and 61%, respectively (R+C Group vs. R group, P=0.081;R+C+S group vs. R group, P=0.035). The 5-yeal distant metastasis-free survival rates were 70%, 85%, 65%, and 73%, respectively (R+C group vs. R+S group, P=0.064;R+C group vs. R+S group, P=0.016). Conclusions Compared with radiotherapy alone, comprehensive treatment with different combinations can improve the long-term survival of LA-HNSCC patients. Radiotherapy combined with chemotherapy has a tendency to improve the distant metastasis-free survival rate, The optimal comprehensive treatment modality that improves the overall survival of LA-HNSCC patients remains to be explored.
		2020 Vol. 29 (7): 502-507 [Abstract] ( 201 ) [HTML 1KB] [ PDF 1586KB] ( 0 )

Thoracic Tumors

	508	Comparison of gross target volumes based on four-dimensional CT, positron emission tomography-computed tomography and magnetic resonance imaging in thoracic esophageal cancer
		Li Huimin, Li Jianbin, Li Fengxiang, Zhu Youzhe, Zhang Yingjie, Guo Yanluan, Xu Min, Shao Qian, Liu Xijun
		Objective To investigate the application value of ¹⁸F-FDG PET-CT combined with MRI in the radiotherapy for esophageal carcinoma by comparing the differences in the gross target volume (GTV), position length delineated on the end expiratory (EE) phase of 4DCT, PET-CT and T2-weighted MRI (T2W-MRI). Methods Twenty-six patients with thoracic esophageal cancer scheduled to receive concurrent chemoradiotherapy sequentially underwent 3DCT, 4DCT,PET-CT and enhanced MRI for thoracic localization. All images were fused with the 3DCT images by deformable registration. GTVCT, GTV50% GTVPET2.5, GTVMRI and GTVDWI were delineated on 3DCT, the EE phase of 4DCT images, PET-CT with the thresholds of SUV≥2.5, T2W-MRI and diffusion-weighted images, respectively. Results GTVPET2.5 was significantly larger than GTV50% and GTVMRI (P<0.001 and P=0.008),whereas the volume of GTVMRI was similar to that of GTV50%(P=0.439). Significant differences were observed between the CI of GTVMRI to GTV50% and GTVPET2.5 to GTV50%(P=0.004). The conformity indexes (CIs) of GTVMRI to GTVCT and GTVPET2.5 to GTVCT were statistically significant (P=0.004 and P=0.039). The CI of GTVMRI to GTVPET2.5 was significantly smaller than that of GTVMRI to GTV50%, GTVMRI to GTVCT, GTVPET2.5 to GTV50% and GTVPET2.5 to GTVCT (P=0.000-0.021). The length of gastroscopy was similar to those of GTVPET2.5 and GTVDWI (both P>0.05), and there was no significant difference in the length between GTVPET2.5 and GTVDWI (P=0.072). Conclusion GTVMRI yields significantly different volume and poor spatial matching compared with GTVPET2.5. The application of PET-CT combined with MRI under respiratory gating system in the delineation of GTV should be used with caution in thoracic squamous esophageal cancer. MRI-DWI can replace PET-CT to help determine the upper and lower boundaries of GTV based on CT images.
		2020 Vol. 29 (7): 508-512 [Abstract] ( 215 ) [HTML 1KB] [ PDF 1244KB] ( 0 )

	513	Effects of different irradiation ranges in definitive intensity-modulated radiotherapy combined with chemotherapy on prognosis of patients with esophageal cancer
		Li Qiaofang, Deng Wenzhao, Zhao Yan, Song Chunyang, Xu Jinrui, Wang Xuan, Zhu Shuchai
		Objective To evaluate the effects of different irradiation ranges in definitive intensity-modulated radiotherapy (IMRT) combined with chemotherapy on the survival of esophageal cancer patients. Methods Clinical data of 360 esophageal cancer patients who received definitive chemoradiotherapy in the Fourth Hospital of Hebei Medical University from 2006 to 2015 were retrospectively analyzed. Among them, 131 patients received elective nodal irradiation (ENI) and 229 patients underwent involved-field irradiation (IFI). Platinum-based chemotherapy was adopted. The overall survival (OS) rate was analyzed by Kaplan-Meier method and Logrank test. Results Until the final follow-up at the end of December 2018, the follow-up rate was 96%. The median follow-up time was 64 months (95%CI:53-76). The median survival time was 24 months (95%CI:20-28). The 1-, 3-, 5-year OS rates were 76.1%, 38.7% and 21.0%, respectively. After propensity score matching, the 1-, 3-, 5-year OS rates were 83.9%, 48.6%, 26.8% vs. 74.0%, 33.8%, 17.5% between the ENI (n=131) and IFI groups (n=131)(P=0.011), respectively. Subgroup analysis showed that patients with male, aged≤66 years, cervical and upper-thoracic location, tumor length≤7cm, tumor volume≤50cm³, T1-3 stage, dosage>60Gy and concurrent chemoradiotherapy obtained better OS rates in the ENI group than their counterparts in the IFI group (all P<0.05). In the ENI group, the total failure rate, locoregional failure rate and distant metastasis rate were significantly lower, whereas the incidence of ≥Grade Ⅲ myelosuppression was remarkably higher than those in the IFI group (all P<0.05). Conclusion Compared with IFI, ENI can significantly improve the survival for patients with early-stage and cervical and upper-thoracic esophageal cancer receiving definitive IMRT combined with chemotherapy.
		2020 Vol. 29 (7): 513-518 [Abstract] ( 178 ) [HTML 1KB] [ PDF 1262KB] ( 0 )

	519	Risk factors and dosimetric limitations for acute radiation pneumonitis after gemcitabine induction chemotherapy for non-small cell lung cancer
		Cui Xiaoying, Sheng Liming, Du Xianghui
		Objective To summarize the incidence of acute radiation pneumonitis (ARP) after gemcitabine induction chemotherapy for non-small cell lung cancer (NSCLC) and identify the high risk factors and dosimetric limitations of ARP after gemcitabine induction chemotherapy. Methods We retrospectively analyzed 191 NSCLC cases who were received gemcitabine induction chemotherapy and chest radiotherapy in radiotherapy department of Zhejiang Cancer Hospital between January 2010 and December 2010.Base line data, treatment information and the incidence of ARP after treatment were collected. The risk factors of ARP were analyzed with univariate and multivariate Logistic regression method. Results A total of 49 patients developed ≥ grade Ⅱ ARP, accounting for 25.7% of all cases. Univariate analysis indicated that the probability of ARP in patients who received the cumulative dose of gemcitabine ≥ 9.0g was 3.45 times higher than that in those treated at a dose of < 9.0g (P=0.015). Radiation dose ≥ 50Gy was significantly correlated with the occurrence of ARP (P=0.008). The risk of ARP was increased by 7.69 times if the time interval between radiotherapy and chemotherapy was within 10 weeks (P=0.047). Among the dosimetric parameters, V5Gy, V20Gy, V30Gy and mean lung dose (MLD) of bilateral lungs were 45%, 22%, 16%, and 1200 cGy respectively. All of them could effectively predict the occurrence of ARP (all P≤0.001). Multivariate analysis indicated that only radiotherapy dose (P=0.044) and V5Gy(P=0.02) were the independent predictors of ARP. Conclusions For NSCLC patients who receive gemcitabine induction chemotherapy, the cumulative dose of gemcitabine, the interval time between chemotherapy and radiotherapy and the radiation dose are associated with the occurrence of ARP.We should strictly limit the total lung dosimetric parameters, such as V5Gy, V20Gy, V30Gy and MLD to reduce the incidence of ARP.
		2020 Vol. 29 (7): 519-522 [Abstract] ( 201 ) [HTML 1KB] [ PDF 710KB] ( 0 )

	523	Clinical outcome of radiotherapy for primary tumors in stage Ⅳ non-small cell lung cancer complicated with malignant pleural effusion
		Wei Tianyu, Ma Zhu, Chen Xiaxia, Li Xiaoyang, Ouyang Weiwei, Su Shengfa, Li Qingsong, Geng Yichao, Yang Wengang, Hu Yinxiang, Li Huiqin, Lu Bing
		Objective To retrospectively analyze the clinical efficacy and safety of three-dimensional radiotherapy for the primary tumors in patients with stage Ⅳ non-small cell lung cancer complicated with malignant pleural effusion (MPE-NSCLC). Methods A total of 198 patients who were initially pathologically diagnosed with MPE-NSCLC from January 2007 to April 2018 were enrolled and divided into the untreated group (n=45), drug group (n=57) and radiotherapy group (n=96), respectively. The short-term efficacy, overall survival (OS) and adverse events in the drug and radiotherapy groups were analyzed. The OS rate was analyzed by Kaplan-Meier method and log-rank test. Clinical prognosis was evaluated by multivariate Cox's regression model. Results In the radiotherapy group, the objective response rate and non-response rate was 54% and 46%, significantly better than 25% and 75% in the drug group (P=0.007). In the radiotherapy group, the 1-, 2-, 3-, 5-year OS and median survival was 47%, 18%, 6%, 1% and 12 months, remarkably higher than 15%, 3%, 2%, 0% and 5 months in the drug group, respectively (all P<0.001). Multivariate Cox's regression analysis showed that radiotherapy for the primary tumors was an independent prognostic factor to prolong the OS (P<0.001). Radiotherapy at a dose of ≥63Gy and 4-6 cycles of chemotherapy tended to prolong the OS (P=0.063 and 0.071). The OS of patients with EGFR mutation receiving radiotherapy combined with molecular target therapy was significantly better than that of those with unknown EGFR status treated with radiotherapy and chemotherapy (P=0.007). Addition of radiotherapy for the primary tumors did not significantly increase the incidence of adverse events (P>0.05). Conclusion Addition of three-dimensional radiotherapy for the primary tumors in MPE-NSCLC patients may prolong the OS and yield tolerable adverse events.
		2020 Vol. 29 (7): 523-528 [Abstract] ( 180 ) [HTML 1KB] [ PDF 753KB] ( 0 )

Abdominal Tumors

	529	Correlation analysis between MRI parameters and prognosis in locally advanced rectal cancer patients receiving chemoradiotherapy
		Chen Silin, Li Shuai, Li Ning, Liu Wenyang, Jiang Liming, Jiang Jun, Ren Hua, Wang Shulian, Song Yongwen, Liu Yueping, Fang Hui, Lu Ningning, Tang Yu, Qi Shunan, Chen Bo, Lei Junqin, Shi Jinming, Li Yexiong, Jin Jing, Tang Yuan
		Objective To investigate the relationship between MRI parameters and clinical prognosis before and after chemoradiotherapy in patients with locally advanced rectal cancer. Methods Clinical and follow-up data of 96 patients with locally advanced rectal cancer who were initially treated in the Cancer Hospital of Chinese Academy of Medical Sciences from 2015 to 2017 were retrospectively analyzed. All patients received preoperative chemoradiotherapy, followed by delayed radical surgery at 6-13 weeks after radiotherapy.MRI assessment was performed twice around radiotherapy which were within 4 weeks before the treatment and 4-8 weeks after it.Correlation analysis was utilized to determine the association between MRI assessment and 3-year disease-free survival (DFS). Results Of the all patients, 80 (83%) had T3 stage, 16(17%) had T4 stage, 14 (15%) had N0 stage, and 82 (86%) had N1-2 stage.Among them, 69(72%) and 58(60%) patients were positive for MRF and EMVI. The median dose of radiotherapy was 50Gy, and all patients were sensitized by simultaneous capecitabine. After chemoradiotherapy, T-downstage rate of the whole group was 24%, and 50% for the N-downstage rate. The MRF-and EMVI-positive rates were significantly decreased to 37% and 27% after chemoradiotherapy (both P<0.001). Univariate and multivariate analyses showed that N staging and EMVI status change were significantly correlated with the 3-year DFS. Conclusion MRI after concurrent chemoradiotherapy reveals that positive EMVI throughout the treatment and N1-N2 staing are poor prognostic factors of DFS, suggesting the need for improving the treatment.
		2020 Vol. 29 (7): 529-534 [Abstract] ( 192 ) [HTML 1KB] [ PDF 1117KB] ( 0 )

	535	Application of cervix-uterine ITV in volumetric modulated arc therapy for cervical cancer under different bladder filling status
		Ma Jianping, Pan Wenyan, Xia Xinshe, Ye Hongqiang, He Jianli, Bai Xuehong, Feng Yangyang, Kong Wei, Jin Xiaofeng, Zhao Ren
		Objective To investigate the clinical application of cervix-uterine internal target volume (ITV) in volume-modulated arc therapy (VMAT) for cervical cancer under different bladder filling conditions, aiming to obtain more accurate planning target volume (PTV). Methods Sixty-two patients with cervical cancer receiving radiotherapy rather than surgery were selected and randomly divided into the study (n=31) and control groups (n=31). In the study group, individualized ITV, PTV and PTV margin were obtained under three bladder filling status by localization CT scan to compare the VMAT. The target area and organs at risk (OARs) within the target area were statistically compared between two groups. The target missing rate in CBCT, adverse events and short-term efficacy of radiotherapy were analyzed in two groups. Results There was no significant difference in the volume of target area and OARs in the target area between two groups (both P>0.05). In the study group, the target missing rate and target missing volume were significantly lower compared with those in the control group (both P<0.05). There was no significant difference in the incidence of acute radiation-induced adverse events between two groups (P>0.05). The 1-, 2-year overall survival and progress-free survival did not significantly differ between two groups (all P>0.05). One patient in the study group had uterine recurrence and 2 cases in the control group. Conclusion Application of individualized cervix-uterine ITV and PTV in definitive VMAT under different bladder filling conditions can improve the accuracy of target area contouring and improve the local control rate in cervical cancer patients.
		2020 Vol. 29 (7): 535-539 [Abstract] ( 229 ) [HTML 1KB] [ PDF 874KB] ( 0 )

Physics · Biology · Technique

	540	Planning target volume-Is it still suitable for intensity modulated proton therapy for lung cancer?
		Shang Haijiao, Pu Yuehu, Chen Zhiling, Shen Liren, He Xiaodong, Huang Xiaoyan, Wang Yuenan
		Objective To demonstrate the concept of planning target volume (PTV) is not suitable for intensity proton therapy (IMPT) in lung cancer, plan differences were compared based on the concept of PTV and Internal target volume (ITV), aiming to provide clinical reference.Methods Six patients were retrospectively selected and approved by the local ethics committee. Each of the six patients received two IMPT plans based on a synchronous accelerator model,developed by SINAP team (Shanghai Institute of Applied Physics, China Academy Science University) and commercial treatment system:one with the PTV-based robust IMPT (PTV-IMPT) plan and the other with ITV-based robust IMPT (ITV-IMPT) plan. Three beams were set in all plans, and the final dose was calculated using Monte Carlo dose algorithm. The plan quality androbustnessof PTV-IMPT and ITV-IMPT plans were evaluatedquantitatively. Results Compared to the PTV-IMPT plan, ITV-IMPT plan showed better target conformity index (conformability index:0.58 vs.0.43),better homogeneity index (homogeneity index:0.96 vs.0.92), lower V5Gy innormal lung tissue(13.1% vs.13.5%) and maximum dose in spinal cord (8.9 Gy vs. 9.5 Gy) as well as plan monitor unit (MU:338 vs. 401) . In addition, ITV-IMPT plan showed more robust in target coverage (0.003-0.032 vs. 0.02-0.28), andnormal lung tissue was also found a bit robust in the ITV-IMPT plan(0.06-0.11,0.07-0.13). Conclusions Compared with the PTV-IMPT plan, ITV-IMPT plan has the advantages of high planning quality, well robustness and better tumor motion mitigation. Therefore, ITV concept is recommended to be applied in the IMPT plan for lung cancer.
		2020 Vol. 29 (7): 540-545 [Abstract] ( 209 ) [HTML 1KB] [ PDF 2559KB] ( 0 )

	546	Application of equivalent uniform dose optimization in intracavitary/interstitial brachytherapy for cervical cancer
		Zhou Lin, Jiang Shan, Yang Zhiyong, Zhang Daguang, Zeng Jing
		Objective To investigate the application of equivalent uniform dose (EUD) in the combination of intracavitary and interstitial brachytherapy (combined-BT) for cervical cancer. Methods Twenty cervical cancer patients treated with combined-BT in Tianjin Medical University Cancer Institute and Hospital were recruited in this study. For each patient, treatment plans were optimized based on EUD and hybrid EUD (h-EUD). The results were statistically compared with predefined plans generated by Oncentra Brachy v4.3 using hybrid inverse planning optimization (HIPO). Furthermore, virtual uniform interstitial experiments were applied to evaluate the advantage of EUD. Results All three plans showed consistent conformity index. Compared with the HIPO plans, the average D2cm³ of bladder, rectum and intestine in the EUD plans were decreased by 0.22 Gy, 0.23 Gy and 0.28 Gy, and those in the h-EUD plans were declined by 0.16 Gy, 0.22 Gy and 0.24 Gy, respectively. The average EUD of bladder, rectum and intestine in the EUD plans were decreased by 0.14 Gy, 0.20 Gy and 0.15 Gy, and those in the h-EUD plans were declined by 0.20 Gy, 0.13 Gy and 0.16 Gy, respectively (all P<0.05). The virtual interstitialexperiment showed EUD could significantly improve the dose sparing for organs at risk (OARs). Conclusion The application of EUD can significantly improve the dose sparing for normal tissues without compromising dose homogeneity and conformity during combined-BT for cervical cancer.
		2020 Vol. 29 (7): 546-550 [Abstract] ( 212 ) [HTML 1KB] [ PDF 736KB] ( 0 )

	551	Dosimetry test of domestically-made accelerator intensity-modulated radiation therapy and volumetric-modulated arc therapy
		Jiang Dazhen, Liu Hui, Wang Xiaoyong, Wang Dajiang, Shen Jiuling, Chen Ji, Chen Cheng, Zhao Hongli, Bao Zhirong, Zhang Jun
		Objective To create AAPM TG 119 test plans for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) in order to evaluate the accuracy of the United Imaging Healthcare's URT treatment planning system (URT-TPS). The plans were delivered to the phantom using the United Imaging Healthcare's URT-Linac 506C. Methods The overall accuracy of IMRT and VMAT planning, measurement, and analysis were evaluated for four test geometries provided by American Association of Physicists in Medicine (AAPM) Task Group Report 119(TG-119) on multi-target, prostate, head and neck and C-shape (easy). The dose distributions were measured in the coronal plane. The point measurements were measured by a Farmer type ion chamber and fluence measurements were completed with film and Delta4 phantom, respectively. Measured planar dose distributions were analyzed using gamma index with criteria 3%/3 mm. Results For IMRT and VMAT plans, the planning results matched the TG-119 planning results. Measured point doses of IMRT and VMAT were within 2.62% and 3.90% of the planned doses, respectively. Measured film dosimetry gamma values of IMRT and VMAT were> 97.50% and> 93.27%, respectively. Conclusion Based on these analyses which were performed in line with the TG119 recommendations, it is evident that the URT treatment planning system and URT-Linac 506C have commissioned IMRT and VMAT techniques with adequate accuracy.
		2020 Vol. 29 (7): 551-553 [Abstract] ( 308 ) [HTML 1KB] [ PDF 685KB] ( 0 )

	554	Application of TG100 report in process quality control of intensity-modulated radiotherapy
		Song Rui, Zhang Jun, Shen Jiuling, Liu Zhiyong, Gao Xuefen, Ni Gang, Chen Jing
		Objective To analyze the intensity-modulated radiotherapy (IMRT) process based on the TG100 report, aiming to improve the quality control method and guarantee the safety and quality of IMRT. Methods Based on the TG100 report, a risk analysis team was established. The flow chart of overall and each sub-step of IMRT was constructed. The failure mode and effect analysis method were adopted to determine all potential error modes in the process. The probability of of the error mode, the probability of being checked out and the severity of the effect of the error mode on the clinical bed were evaluated based on the pre-set scoring standard. The priority value of each error mode was calculated and ranked from high to low priority value. The top 20% is defined as the high-risk error mode, which was analyzed by error tree to improve the quality control method. Results IMRT consisted of 11 main steps and 41 sub-steps, and 180 failure modes were detected. The priority values were ranged from 30 to 178. A total of 36 high-risk failure modes were found. The top 5 high-risk failure modes (RPN) consisted of setup error (178), electronic portal imaging device (EPID) registration (172), contouring error (166), treatment delivery error (160) and prescription dose error (156). Conclusion TG100 report is practical and convenient to utilize, which can effectively and systematically improve IMRT process and provide safety and quality assurance of IMRT process.
		2020 Vol. 29 (7): 554-557 [Abstract] ( 222 ) [HTML 1KB] [ PDF 869KB] ( 0 )

	558	Effect of mannose on the radiosensitivity of six non-small cell lung cancer cell lines
		Ge Hong, Luo Hui, Liu Kangdong, Jia Xuechao, Nie Wenna, Zhang Qiqi, Lu Bingbing, Yang Ran, Wang Nan, Song Shuai, Jiao Ruidi
		Objective To investigate the effect of mannose on the radiosensitivity of six human non-small cell lung cancer cell lines and its possible mechanism. Methods The expression of mannose phosphate isomerase in six lung cancer cell lines were detected by Western blot. The inhibitory effect of mannose on the proliferation of lung cancer cell lines were observed by MTT assay. When irradiated with 0, 2, 4, 6, 8 and 10Gy, the effect of mannose on the radiosensitivity of six lung cancer cell lines was detected by plate clone formation assay, respectively;and the apoptosis rates of normal control, mannose, irradiation and combined groups were detected by flow cytometry. Results The expression levels of mannose phosphate isomerase were different among six lung cancer cell lines. Among them, A549 cells had the highest expression level and H460 cells showed the lowest expression level. When aDministrated with 11.1 mmol/L mannose, the same inhibitory effect was observed on both A549 and H460 cell lines. Moreover, the inhibitory effect on H460 cell line was significantly increased with the increase of mannose concentration. In addition, aDministration of 11.1 mmol/L mannose could significantly increase the radiosensitivity and apoptosis rate of H460 cell line. However, it exerted limited effect upon the radiosensitivity and apoptosis rate of A549 cell line. Conclusion In six lung cancer cell lines with high expression of mannose phosphate isomerase, the aDministration of mannose can enhance the radiosensitivity of partial tumors cells.
		2020 Vol. 29 (7): 558-562 [Abstract] ( 207 ) [HTML 1KB] [ PDF 1776KB] ( 0 )

	563	Silencing lncRNA HOTTIP affects radiosensitivity of non-small cell lung cancer cell lines by up-regulating miR-663a
		Wei Shaoxian, Niu Rui, Yang Hailin, Li Xia, Wang Qingxu, Liu Jun,Hu Yongqiang
		Objective To investigate the effect of lncRNA HOTTIP on the radiosensitivity of four non-small cell lung cancer cell lines cultured in vitro by regulating the expression of miR-663a. Methods Four non-small cell lung cancer cell lines (H838, H157, A549, and H1299) were irradiated with different radiation intensities (0, 2, 4, 6, and 8 Gy). Cell survival was detected by colony formation assay. The expression levels of HOTTIP and miR-663a were detected by qRT-PCR. A549 and H1299 cells were selected for the subsequent experiment. After silencing HOTTIP and/or over-expressing miR-663a, cell survival was detected by colony formation assay. Cell apoptosis was detected by flow cytometry. The expression levels of Cleaved caspase-3, Cleaved PARP andγ-H2AX were quantitatively measured by Western blot. The targeting relationship between HOTTIP and miR-663a was vefiried by dual luciferase reporter assay and qRT-PCR. Results The expression of HOTTIP was up-regulated, whereas that of miR-663a was down-regulated in the radiation-resistant H157, A549 and H1299 cells. Silencing HOTTIP or over-expressing miR-663a inhibited the survival of A549 and H1299 cells (radiosensitization ratios were 1.562 and 1.507, respectively), promoted the expression of Cleaved caspase-3, Cleaved PARP and γ-H2AX, and accelerated cell apoptosis induced by radiation exposure. miR-663a was a target gene of HOTTIP, and HOTTIP negatively regulated the expression of miR-663a. The inhibition of miR-663a reversed the effect of silencing HOTTIP on the radiosensitivity of non-small cell lung cancer cells. Conclusion Silencing HOTTIP can suppress the survival of non-small cell lung cancer cells and promotes cell apoptosis by up-regulating the expression of miR-663a, thereby enhancing the radiosensitivity of non-small cell lung cancer cell lines.
		2020 Vol. 29 (7): 563-568 [Abstract] ( 195 ) [HTML 1KB] [ PDF 761KB] ( 0 )

	569	Establishment of an accurate C57BL6/J mouse model of acute radiation-induced enteritis based on small animal radiation research platform
		Tu Yeqiang, Tang Qiu, Zhang Peng, Mu Hanzhou, Ni Juan, Zhou Qiong, Yan Dingding, Lyu Xiaojuan
		Objective To establish an accurate C57BL6/J mouse model of acute radiation-induced enteritis based on small animal radiation research platform (SARRP). Methods Forty-eight female mice were randomly divided into the following four groups:blank control group, 6Gy irradiation group, 9Gy irradiation group and 12Gy irradiation group. Based on the SARRP, the mice in the irradiation groups were exposed to a single fraction dose of 6Gy, 9Gy and 12Gy at a dose rate of 4Gy/min, respectively. The general condition, body weight andpathological changes of the small intestine of mice were observed. ResultsAfter CT scanning, the target area and normal tissues were delineated. According to the dose distribution of the target area and the protection of spinal cord, the AP-PA field irradiation scheme at the isocentric level was adopted. The average irradiation time in the 6, 9 and 12Gy groups was 163, 252 and 328 seconds, respectively.The survival rates of mice in the 6, 9 and 12 Gy groups were 100%, 100% and 50% 15 days after irradiation.The body weight of mice in the 6Gy (P=0.035), 9Gy (P=0.002) and 12Gy groups (P<0.001) was decreased significantly on the 5^th day after irradiation, and gradually increased on the 10^th day. With the increase of irradiation dose, the villus and gland injury was aggravated. Compared with the blank control group, the villus length in the 9 and 12Gy groups was significantly shorter (both P<0.001), and theintestinal wall thickness in the irradiation groups was significantly thinner (all P<0.001). Conclusions ARRP can provide accurate target location, planned screening and accurate dose delivery in the establishment of C57BL6/J mouse model of acute radiation-induced enteritis. The C57BL6/J mouse model of acute radiation-induced enteritis can be successfully established by a single fraction total-abdominal irradiation of 6-9Gy.
		2020 Vol. 29 (7): 569-573 [Abstract] ( 199 ) [HTML 1KB] [ PDF 2980KB] ( 0 )

	574	Effect and possible mechanism of BMI-1 gene on radiosensitivity of human pancreatic cancer SW1990 cell line
		Wang Mincong, Ma Hongbing, Jin Yingying, Han Lili, Huang Lanxuan, Xie Fei
		Objective To evaluate the effect and possible mechanism of B-cell-specific moloney murine leukemia virus insertion site 1(BMI-1) on the radiosensitivity of pancreatic cancer SW1990 cell line. Methods According to our previous study results, 4Gy X-ray and down-regulation of BMI-1 expression were adopted as intervention conditions. The effect on the proliferation of SW1990 cells was assessed by clony formation assay. The effect on cell apoptosis and cell cycle was evaluated by flow cytometry. The effect upon the epithelial-mesenchymal transition (EMT) was determined by Western blot. Results Clony formation assay and flow cytometry found that the lowest cell proliferation ability and the highest apoptotic rate were obtained after BMI-1 down-regulation and 4Gy X-ray compared with other groups (all P<0.05). Flow cytometry revealed that the proportion of G0/G1 phase was significantly decreased, whereas the G2/M phase was remarkably increased in pancreatic cancer stem cells treated with 4Gy X-ray compared with the control group (both P<0.05). Nevertheless,opposite results were obtained after down-regulation of BMI-1 expression. Western blot showed that the expression of E-cadherin was up-regulated, whereas that of Vimentin was down-regulated following 4Gy X-ray (both P<0.05). Conclusion Downregulation of BMI-1 expression can enhance the radiosensitivity of pancreatic cancer SW1990 cells, and its mechanism may be related to cell cycle and EMT.
		2020 Vol. 29 (7): 574-577 [Abstract] ( 196 ) [HTML 1KB] [ PDF 872KB] ( 0 )

Review Articles

	578	Research progress on multi-disciplinary combined therapy for locally advanced hypopharyngeal carcinoma
		Luo Xi, Yi Junlin
		Hypopharyngeal carcinoma is one of the worst prognosis among head and neck cancers with a reported 5-year overall survival (OS) rate of 25%-35%. Because of the important position and function of hypopharynx, the preservation of organ function and improvement of survival are equally important. Multi-disciplinary combined treatment modality is playing a more and more pivotal role. The optimal combined modalities of surgery, radiotherapy, chemotherapy and molecular targeted therapy have been constantly modified, so the survival rate and organ function preservation rate have been gradually increased. As the surge of immunotherapy, immunotherapy combined with chemoradiotherapy in the treatment of hypopharyngeal cancer has become a highlight field. In this article, the research progress on multi-disciplinary combined treatment and the future direction in the treatment of hypopharyngeal carcinoma were mainly introduced.
		2020 Vol. 29 (7): 578-582 [Abstract] ( 184 ) [HTML 1KB] [ PDF 772KB] ( 0 )

	583	Clinical value and research progress on multimodal radiological and radiomic examinations in evaluating the clinical efficacy of chemoradiotherapy for esophageal cancer
		Han Weiming, Xiao Zefen
		With the development of radiology, it has been found that clinical radiological examinations can provide evidence for evaluating the clinical efficacy of chemoradiotherapy for esophageal cancer. In this article, the clinical values of various radiological and radiomic examinations in predicting the clinical prognosis of esophageal cancer patients treated with chemoradiotherapy were reviewed and discussed.
		2020 Vol. 29 (7): 583-588 [Abstract] ( 193 ) [HTML 1KB] [ PDF 778KB] ( 0 )

	589	Research progress on radical radiation dose for esophageal carcinoma
		Zhao Jingjing, Pang Qingsong, Wang Ping
		Concurrent chemoradiotherapy is widely accepted as the standard treatment for locally advanced inoperable esophageal cancer, and 50.0 to 50.4Gy is recommended as the optimal dose for definitive treatment by the international guidelines. However, esophageal cancer in China is quite different from that in western countries in terms of the pathological type and biological characteristics, and a radiation dose of 60Gy is recommended. Whether dose-escalated radiotherapy could bring survival benefits remains to be urgently resolved. Some scholars indicate that the higher radiation dose is correlated with better local tumor control and more favorable survival outcomes, whereas others hold the view that increased toxicity and no survival benefits have been observed in the high dose arm. Therefore, this review is to evaluate the impact caused by different radiation doses and assess the clinical efficacy, aiming to individualize the radiation dose.
		2020 Vol. 29 (7): 589-592 [Abstract] ( 170 ) [HTML 1KB] [ PDF 742KB] ( 0 )

	593	Research progress on anti-vascular endothelial growth factor therapy, radiotherapy and immunotherapy for tumors
		Yu Qin, Yu Rong
		At present, in many preclinical and clinical studies, the mechanism of action, combination therapy, therapeutic efficacy, and side effects ofvascular endothelial growth factor(VEGF) inhibitors in combination with radiotherapy and immunotherapy are being explored. Some studies have reported improved tumor control after the addition of anti-VEGF intervention to radiotherapy. Nevertheless, how to administer these three modalities to achieve optimal response with minimal toxicity remains to be investigated. In this article, the mechanism and research progress on anti-VEGF therapy, radiotherapy and immunotherapy were reviewed.
		2020 Vol. 29 (7): 593-596 [Abstract] ( 181 ) [HTML 1KB] [ PDF 746KB] ( 0 )

中华放射肿瘤学杂志

News

More.....

Cooperation unit

友情链接

China Association for
　Science and Technology

Chinese Medical Association

Cancer Hospital of Chinese
　Academy of Medical
　Sciences Department of
　Radiation Oncology

Chinese Anti-Cancer
　Association

Chinese Journal of Lung
　Cancer

Cqvp

CNKI

Wanfang Data

More....