等效均匀剂量在宫颈癌腔内联合插植近距离治疗中的应用

doi:10.3760/cma.j.cn113030-20180810-00444

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Abstract Objective To investigate the application of equivalent uniform dose (EUD) in the combination of intracavitary and interstitial brachytherapy (combined-BT) for cervical cancer. Methods Twenty cervical cancer patients treated with combined-BT in Tianjin Medical University Cancer Institute and Hospital were recruited in this study. For each patient, treatment plans were optimized based on EUD and hybrid EUD (h-EUD). The results were statistically compared with predefined plans generated by Oncentra Brachy v4.3 using hybrid inverse planning optimization (HIPO). Furthermore, virtual uniform interstitial experiments were applied to evaluate the advantage of EUD. Results All three plans showed consistent conformity index. Compared with the HIPO plans, the average D2cm³ of bladder, rectum and intestine in the EUD plans were decreased by 0.22 Gy, 0.23 Gy and 0.28 Gy, and those in the h-EUD plans were declined by 0.16 Gy, 0.22 Gy and 0.24 Gy, respectively. The average EUD of bladder, rectum and intestine in the EUD plans were decreased by 0.14 Gy, 0.20 Gy and 0.15 Gy, and those in the h-EUD plans were declined by 0.20 Gy, 0.13 Gy and 0.16 Gy, respectively (all P<0.05). The virtual interstitialexperiment showed EUD could significantly improve the dose sparing for organs at risk (OARs). Conclusion The application of EUD can significantly improve the dose sparing for normal tissues without compromising dose homogeneity and conformity during combined-BT for cervical cancer.

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	Articles by authors
	Zhou Lin
	Jiang Shan
	Yang Zhiyong
	Zhang Daguang
	Zeng Jing

Key words： Equivalent uniform dose Hybrid inverse planning optimization Dose optimization Cervical neoplasm/brachytherapy

Received: 10 August 2018

Fund:National Natural Science Foundation of China (51775368,5171101938);Science and Technology Planning Project Fund of Guangdong Province (2017B0210004)

Corresponding Authors: Jiang Shan, Email:shanjmri@tju.edu.cn

Cite this article:

Zhou Lin,Jiang Shan,Yang Zhiyong et al. Application of equivalent uniform dose optimization in intracavitary/interstitial brachytherapy for cervical cancer[J]. Chinese Journal of Radiation Oncology, 2020, 29(7): 546-550.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20180810-00444 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2020/V29/I7/546

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