Abstract: 【Purpose/significance】More and more scholars are now focusing on the research of entrepreneurial ecosystem. To clarify
the synergistic effects between entrepreneurial ecosystem evolution and knowledge governance, a synergistic model of entrepreneurial ecosystem evolution and its multi-actor knowledge governance structure is constructed.【Method/process】Relevant studies on entre? preneurial ecosystems are reviewed and sorted out, different stages of the life cycle of entrepreneurial ecosystems and their matching knowledge governance structures are analyzed, and the synergistic mechanisms of multi-actor knowledge governance structures based on different entrepreneurial ecosystem types are further explained.【Result/conclusion】In the initial stage of entrepreneurial ecosys? tem, the main knowledge governance structure is hierarchical governance. The interaction of the participants in ecosystem depends on the unidirectional knowledge flow dominated by the key agent, reflecting the characteristics of synergistic knowledge evolution; In the mature stage, the main structure of knowledge governance is relational governance. The key actors in the system no longer have the core status. All participants play a role based on two-way knowledge flow, reflecting the evolution characteristics of knowledge collabo? ration and competition.【Innovation/limitation】A model of entrepreneurial ecosystem evolution and its synergistic multi-actor knowl? edge governance structure is constructed, and the empirical approach can be used to provide practical guidance for entrepreneurial ecosystem research in future studies.