Abstract: 【Purpose/significance】This paper discusses the evolution mechanism of collaborative symbiosis among knowledge popula?
tions in the knowledge ecosystem,and analyzes the evolution and development of industry university research cooperative innovation
mode under different symbiosis modes by constructing the symbiosis model of enterprises and university research institutes.【Method/
process】The simulation experiment of industry university research cooperative innovation under different symbiosis modes is carried
out,and the symbiosis mode is analyzed by introducing the industry university research innovation index as the data source.【Result/
conclusion】The simulation experiment shows that the symbiotic model among knowledge populations can gradually guide the transfor? mation in the knowledge ecosystem. The development of each knowledge population is affected not only by the initial density and de? velopment speed,but also by other populations in the symbiotic environment,and the mutually beneficial symbiotic model is the prem? ise to maintain the stability of the knowledge ecosystem. It is found that in the industry university research cooperation system,the rapid growth scale of enterprises cannot determine their dominant position in the knowledge ecosystem; For the whole knowledge eco? system,the reasonable selection of symbiotic model is an important condition for the collaborative symbiosis of knowledge populations.【Innovation/limitation】The synergistic symbiotic paths of different knowledge subjects in the knowledge ecosystem will be analyzed to provide reference experience for the development model of industry-university-research cooperation in China.