Barkol is located in the east of Xinjiang Tianshan and known as the “Xinjiang throat”. Besides, Barkol is earthquake-prone regions in Xinjiang during Qing dynasty. A 7.5 earthquake broke out from May 3 to 5 in the twenty-two years of the Emperor Daoguang period. About 14 earthquake records of Qing dynasty recorded the issues relating to the earthquake, including the memorials instructed by the emperor the imperial edicts of the Emperor Daoguang,and the memorial copies kept in the first Historical Archiues of China and the Palace Museum in Taipei. It is rare in the history of the earthquakes in Xinjiang and even in China in the Qing dynasty. According to the files above, this paper summarizes the earthquake situation of Barkol in Xinjiang, and discusses the disaster relief countermeasures suchas pension victims, individual donations of officials, borrowing silver, repair city with donations, troops sent, personnel to be used again and officials promoted. Then it analyzes the pros and cons of these strategies, in order to refer the reasonable countermeasures and guard against the wrong countermeasures. It has important practical significance for today's work of the disaster prevention and reduction.