Chinese Journal of Radiation Oncology

中华放射肿瘤学杂志

中华放射肿瘤学杂志

Office

Journal

Archive

RSS

Download

Instruction

Template

Quick Search

Advanced Search

Chinese Journal of Radiation Oncology

	2022 Vol.31 Issue.3 Published 2022-03-15

	Head and Neck Tumors Abdominal Tumors Thoracic Tumors Review Articles Investigation Research Physics·Technique·Biology Benign Diseases

Investigation Research

	223	The allocation and equity of personnel and facilities of radiotherapy in the county hospitals of Chinese mainland in 2019
		Xing Yu, Wang Lyuhua, Zhang Ye
		Objective To examine the status of personnel and facilities of radiotherapy in county hospital of Chinese mainland and to evaluate the equity of allocation. Methods All the county level radiotherapy units were chosen for study, and the data were extracted from the 9^th national survey on radiation oncology departments conducted by Chinese Society of Radiation Oncology of Chinese Medical Association from April 10, 2019 to September 20, 2019. Descriptive statistics and statistical analysis were performed. For the further analysis on the equity, the Gini coefficient, Theil index and agglomeration degree were calculated. Results The number of county level radiotherapy units was 191 in the eastern region, 172 in the central region and only 59 in the western region, and there was no radiotherapy unit in the county area of some provinces in the western region. For the counties with larger population (population over 500 thousand) in Chinese mainland, 23.4% of the counties in the western region had radiotherapy units, lower compared to the eastern region (48.9%) and central region (41.8%). The Gini coefficients of all kinds of radiotherapy health resources according to population allocation were in alert states, and in highly unfair states according to geographical allocation. The intra-regional gap in radiotherapy resource allocation was larger than the inter-regional gap, and the intra-regional gap mainly came from the western region. HRAD_i, HRAD_i/PAD_i in the eastern and central regions were all greater than 1, while those in the western region were all less than 1. Conclusions The overall configuration of county level radiotherapy units in Chinese mainland is insufficient, and there is a regional difference. The fairness of geographical allocation of radiotherapy resources is generally poor. Radiotherapy resources should be scientifically configured to improve the fairness of radiotherapy resource distribution.
		2022 Vol. 31 (3): 223-228 [Abstract] ( 628 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Head and Neck Tumors

	229	Meta-analysis of efficacy and safety of induction chemotherapy combined with radiotherapy±concurrent chemotherapy for nasopharyngeal carcinoma patients in the era of intensity-modulated radiation therapy
		Yang Jie, Liang Zhongguo, Jiang Yuting, Chen Kaihua, Li Ling, Qu Song, Zhu Xiaodong
		Objective To compare the efficacy and adverse events of induction chemotherapy combined with radiotherapy alone (IC+RT) and induction chemotherapy combined with concurrent chemoradiotherapy (IC+CCRT) for nasopharyngeal carcinoma in the era of intensity-modulated radiation therapy in this Meta-analysis. Methods Retrospective or randomized controlled clinical studies published between 2010 and 2020 were searched from the Cochrane Library, PubMed, and Web of Science databases. The selected studies included nasopharyngeal carcinoma patients treated with IC+ CCRT or IC+ RT. STATA 12software was used to combine the hazard ratio (HR), risk ratio (RR) and 95% confidence interval (CI), and random or fixed effect models were used for statistical analysis. Results A total of 2483 patients from eight retrospective studies were included. The overall survival in the IC+CCRT group was similar to that in the IC+RT group (HR=0.78, 95%CI:0.58-1.04, P=0.091). However, the distant metastasis-free survival (HR=0.56, 95%CI:0.42-0.74, P<0.001) and progression-free survival (HR=0.65, 95%CI:0.54-0.77, P<0.001) were improved in the IC+CCRT group compared with those in the IC+RT group. In terms of adverse reactions, the acute adverse reactions in the IC+CCRT group were increased significantly compared with those in the IC+RT group. Conclusions In the treatment of nasopharyngeal carcinoma, the overall survival of two treatment modes is similar, but the distant metastasis-free survival and progression-free survival in the IC+CCRT group are better than those in the IC+RT group, whereas the incidence of adverse reactions is also increased. IC+CCRT may be a recommended treatment for nasopharyngeal carcinoma patients, but more research is needed.
		2022 Vol. 31 (3): 229-235 [Abstract] ( 629 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Thoracic Tumors

	236	Safety of thoracic radiotherapy followed by PD-1/PD-L1 inhibitor after induction therapy for extensive-stage small cell lung cancer
		Liu Wenyang, Han Ziming, Wang Jianyang, Zhang Tao, Chen Dongfu, Feng Qinfu, Xiao Zefen, Lyu Jima, Wang Xin, Deng Lei, Wang Wenqing, Zhai Yirui, Wang Zhijie, Wang Jie, Bi Nan, Zhou Zongmei
		Objective To evaluate the safety and tolerance of sequential thoracic radiotherapy combined with PD-1/PD-L1 inhibitors in patients with extensive-stage small cell lung cancer (ES-SCLC) after induction systemic therapy. Methods ES-SCLC patients from a phase I trial and a real-world study were enrolled for those who received thoracic radiotherapy after induction systemic treatment (chemotherapy/chemotherapy combined with PD-1/PD-L1 inhibitors) and consolidated with PD-1/PD-L1 inhibitors. These two studies were both approved by the Ethics Committee of Chinese Academy of Medical Sciences Cancer Hospital (Clinical Trials.gov number, NCT03971214, NCT04947774). Results Between January 2019 and March 2021, a total of 11 patients with ES-SCLC were analyzed, aged 52-73 years, with a median age of 62 years. Among them, five patients (45.5%) received induction chemotherapy and six patients (54.5%) received chemotherapy combined with PD-1/PD-L1 inhibitor, and then all received intensity-modulated thoracic radiotherapy after evaluation of systemic treatment efficacy. Two patients developed treatment-related grade G3-5 toxicity (18.2%, 1 treatment-related pneumonitis and 1 radiation esophagitis). G1-G2hematologic toxicity, pneumonia, and anorexia were common mild toxicities. Only one patient (9.1%) terminated immunotherapy due to immune-related pneumonitis. During a median follow-up time of 12.5 months (range:3.5-16.4 months),the median disease progression-free survival and overall survival was 7.4 months (95%CI:6.9-8.0 months) and 14.6 months (95%CI:9.0-20.2 months), respectively. Conclusions Sequential thoracic radiotherapy followed by PD-1/PD-L1 inhibitor is safe and feasible in patients with ES-SCLC after induction therapy. Given that both thoracic radiotherapy and immunotherapy benefits the ES-SCLC in survival, this comprehensive treatment modality warrants further investigation.
		2022 Vol. 31 (3): 236-241 [Abstract] ( 619 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	242	Study on quality control of mediastinal shift radiotherapy with target volume after operation for non-small cell lung cancer
		Zhang Wei, Zhang Yi, Hong Wei, Ouyang Weiwei, Su Shengfa, Ma Zhu, Li Qingsong, Yang Wengang, Chen Xiaxia, Liu Jie, Lu Bing
		Objective To analyze the mediastinal displacement of target volume in the postoperative radiotherapy (PORT) process for non-small cell lung cancer (NSCLC) and the value of mid-term evaluation. Methods For 100 patients with postoperativeN2stage NSCLC, R1-2 and any N staging, bone anatomy was utilized to measure the change of the first and second CT localization on the same level. Statistical analysis were performed using the WilCoxon, Kruskal-Wallis and χ² tests. The cut-off values were calculated with the receiver operating characteristic (ROC) curve. Results Among the included patients, in the PORT process, the mediastinal displacement in the x (front and rear), Y (left and right) and Z (upper and lower) directions were 0.04-0.53cm, 0.00-0.84cm and 0.00-1.27cm, respectively, and the order of mediastinal displacement distance wasz >Y>X, respectively. According to the ROC curve calculation, the cut-off values were 0.263, 0.352 and 0.405, respectively, which were greater than the cut-off values in 25 cases (25%), 30 cases (30%) and 30 cases (30%), respectively. There was significant difference in the three-dimensionalmediastinal displacement (P=0.007,<0.001 and<0.001). The mediastinal displacement in thex, Y and Z directions had no statistical significance regarding resection site (P=0.355, 0.239 and 0.256) and operation mode (P=0.241, 0.110 and 0.064). Comparative analysis of modified whole group mediastinal shift> and cut-off values, medium-simulation (m-S) and the originally planned radiotherapy shown that there was no significant difference in the incidence of radiation esophagitis (RE) and radiation pneumonitis in PORT patients (all P>0.05);however, the incidence of ≥grade 3 RE in the modified plan after m-S was significantly lower than that in the originally planned PORT patients, which were 0 and 7%, respectively (P<0.001). Conclusions Mediastinal displacement exists in the PORT process of N2 or/and R1-2 cases after radical operation of NSCLC, and obvious movement occurs in 20%-30% of patients. Relocating and modifying the target volume and radiotherapy plan in the middle of the PORT process is beneficial to quality assurance and quality control.
		2022 Vol. 31 (3): 242-247 [Abstract] ( 615 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Abdominal Tumors

	248	Local recurrence pattern of pT1-2N1 breast cancer after modified radical mastectomy —a pooled-analysis of 5442 patients from 12 centers
		Guo Xinyuan, Zhang Yujing, Zhang Na, Tang Yu, Zhao Xuran, Jing Hao, Fang Hui, Wen Ge, Cheng Jing, Shi Mei, Guo Qishuai, Wu Hongfen, Wang Xiaohu, Ma Changying, Li Yexiong, Wang Hongmei, Liu Min, Wang Shulian
		Objective To analyze locoregional recurrence (LRR) pattern of patients with pT1-2N1 breast cancer after modified radical mastectomy, with and without adjuvant radiotherapy (RT). Methods A total of 5442 eligible patients with breast cancer from 12 Chinese centers were included. The LRR sites and the effect of RT at different sites on recurrence in patients with and without RT were analyzed. The Kaplan-Meier method was used to calculate the cumulative LRR rate, and the difference was compared by the log-rank test. Results With a median follow-up time of 63.8 months for the entire cohort, 395 patients developed LRR. The chest wall and supraclavicular fossa were the most common LRR sites, regardless of RT or molecular subtypes. The 5-year chest wall recurrence rates for patients with and without chest wall irradiation were 2.5% and 3.8%(P=0.003);the 5-year supraclavicular lymph nodal recurrence rates for patients with and without supraclavicular fossa irradiation were 1.3% and 4.1%(P<0.001);the 5-year axillary recurrence-free rates for patients with and without axillary irradiation were 0.8% and 1.5%(HR=0.31, 95%CI:0.04-2.23, P=0.219);and the 5-year internal mammary nodal recurrence-free rates for patients with and without internal mammary nodal irradiation were 0.8% and 1.5%(HR=0.45, 95%CI:0.11-1.90, P=0.268). Conclusions The chest wall and supraclavicular fossa are the most common LRR sites of patients with pT1-2N1 breast cancer after modified radical mastectomy, which is not affected by adjuvant RT or molecular subtypes. The chest wall and supraclavicular fossa irradiation significantly reduce the risk of recurrence in the corresponding area. However, axillary and internal mammary nodal irradiation has no impact on the risk of recurrence in the corresponding area.
		2022 Vol. 31 (3): 248-252 [Abstract] ( 612 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	253	Long-term outcomes of watch&wait (W&W) after neoadjuvant treatment in patients with rectal cancer
		Zhao Ying, Tang Yuan, Liu Wenyang, Li Ning, Chen Silin, Shi Jinming, Ma Huiying, Zeng Qiang, Song Yongwen, Wang Shulian, Liu Yueping, Fang Hui, Lu Ningning, Tang Yu, Qi Shunan, Yang Yong, Chen Bo, Li Yexiong, Jin Jing
		Objective To compare the outcomes of watch&wait (W&W) strategy in patients with locally advanced rectal cancer who achieved complete clinical response (cCR) after neoadjuvant therapy, with those who obtained pathological complete response (pCR) after total mesorectal excision (TME). Methods This is a retrospective cohort analysis study. Patients histologically proven with locally advanced rectal adenocarcinoma (stage Ⅱ-Ⅲ) who had received neoadjuvant chemotherapy were eligible between January 2014 and December 2019. In whom we included patients who had cCR offered management with W&W strategy after completing neoadjuvant therapy and follow-up ≥1 year (W&W group),and patients who did not have cCR but pCR after TME (pCR group). The primary endpoints were 3-year and 5-year overall survival (OS), colostomy-free survival (CFS), disease-free survival (DFS), non-local regrowth disease-free survival (NR-DFS), and organ preservation rate. Kaplan-Meier analysis was used for survival analysis and log-rank test was performed. For comparative analysis, we also derived one-to-one paired cohorts of W&W versus pCR using propensity-score matching (PSM). Results A total of 118 patients were enrolled,49 of whom had cCR and managed by W&W, 69had pCR, with a median follow-up period of 49.5 months (12.1-79.9 months). No difference was observed in the 3-year OS (97.1% vs. 96.7%) and 5-year OS (93.8% vs. 90.9%, P=0.696) between the W&W and pCR groups. Patients managed by W&W had significantly better 3-year and 5-year CFS (89.1% vs. 43.5%, P<0.001), better 3-year DFS (83.6% vs. 97.0%) and 5-year DFS (83.6% vs. 91.2%, P=0.047) compared with those achieving pCR. The 3-year NR-DFS (95.9% vs. 97.0%) and 5-year NR-DFS (92.8% vs. 97.0%, P=0.407) did not significantly differ between the W&W and pCR groups. Local regeneration occurred in six cases, and 87.7% of patients had successful rectum preservation in the W&W group. In the PSM analysis (34 patients in each group), absolutely better CFS (90.1% vs. 26.5%, P<0.001) was noted in the W&W group. A median interval of 17.5 weeks was observed for achieving cCR, while only 23.9% of patients achieved cCR within 5 to 12 weeks from radiation completion. Patients with short-course sequential chemoradiotherapy achieved cCR significantly later when compared with those with long-course concurrent chemoradiotherapy (19.0 vs. 9.8 weeks, P<0.001). Conclusions The oncological outcomes of W&W strategy in patients with locally advanced rectal cancer are safe and effective, significantly improving the quality of life. Longer interval for cCR evaluation may improve rectal organ preservation rate.
		2022 Vol. 31 (3): 253-259 [Abstract] ( 613 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Benign Diseases

	260	Preliminary study of stereotactic cardiac radioablation in radiotherapy of ventricular arrhythmia
		Li Jing, Chen Qingyong, Li Guangjun, Li Yan, Zhang Yingjie, Li Changhu, Bai Long, Zhong Renming, He Yinbo, Bai Sen, Yang Qing, Xu Feng
		Objective To introduce the stereotactic cardiac radioablation (SCRA) based on the stereotactic body radiotherapy (SBRT), and comprehensively evaluate the new approach by short-term effectiveness and safety. Methods Patients with ventricular arrhythmia (VA) were evaluated and included in this clinical trial, who were immobilized by vacuum bag and performed simulation with 4-dimensional computed tomography (4DCT). In this study, the planning target volume (PTV) was set as the target to design a SBRT plan using volumetric modulated arc therapy (VMAT), which was evaluated by dose parameters such as R50%, homogeneity index and conformity index, etc. The results of Holter and echocardiography were monitored during the follow-up and compared with the data before treatment. Results Three subjects with ventricular tachycardia (VT) and one with premature ventricular contraction (PVC) received the same prescription of 25Gy in a single fraction. The average volume of PTV was 71.4cm³(60.3-89.4cm³). The average time of beam delivery was 12.0min (4.5-21.0min). And the short-term follow-up lasted for an average of 18 weeks (14-25 weeks), which showed significant decrease in both VT and PVC load without complications. Conclusion This study reports the implementation method of SCRA and proves its short-term effectiveness and safety, but the effects and standards of the key radiotherapy techniques still need to be explored.
		2022 Vol. 31 (3): 260-265 [Abstract] ( 611 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Physics·Technique·Biology

	266	Automatic delineation of craniospinal clinical target volume based on hybrid attention U-net
		Li Hongwei, Ni Chunxia, Chen Shu, Meng Ge, Hu Xiaoyang, Wang Yang
		Objective Hybrid attention U-net (HA-U-net) neural network was designed based on U-net for automatic delineation of craniospinal clinical target volume (CTV) and the segmentation results were compared with those of U-net automatic segmentation model. Methods The data of 110 craniospinal patients were reviewed, Among them, 80 cases were selected for the training set, 10 cases for the validation set and 20 cases for the test set. HA-U-net took U-net as the basic network architecture, double attention module was added at the input of U-net network, and attention gate module was combined in skip-connection to establish the craniospinal automatic delineation network model. The evaluation parameters included Dice similarity coefficient (DSC), Hausdorff distance (HD) and precision. Results The DSC, HD and precision of HA-U-net network were 0.901±0.041,2.77±0.29 mm and 0.903±0.038, respectively, which were better than those of U-net (all P<0.05). Conclusion The results show that HA-U-net convolutional neural network can effectively improve the accuracy of automatic segmentation of craniospinal CTV, and help doctors to improve the work efficiency and the consistent delineation of CTV.
		2022 Vol. 31 (3): 266-271 [Abstract] ( 630 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	272	Comparison of setup errors in supraclavicular regions of lung and esophageal cancer treated with radiotherapy
		Wan Bao, Yang Xu, Huan Fukui, Zhang Yanxin, Feng Xin, Zhao Yu, Wu Yingwei, Geng Songsong, Men Kuo, Hui Zhouguang
		Objective To compare the setup errors in the supraclavicular regions of two different postures (arms placed on each side of the body, namely the body side group;arms crossed and elbows placed above forehead, namely the uplifted group) using the chest and abdomen flat frame fixation device in lung and esophageal cancer. Methods Clinical data of patients with stage Ⅰ to Ⅳ lung or esophageal cancer who received three-dimensional radiotherapy with chest and abdomen flat frame fixation device in our institution from November 2020 to April 2021 were retrospectively analyzed. The setup errors of two postures were compared. Results A total of 56 patients were included, including 31 patients (55%) in the body side group and 25 patients (45%) in the uplifted group. A total of 424 CBCTs were performed in the whole group. The overall setup errors in the X, Y and Z directions were similar in both groups (P>0.05). The setup errors of sternoclavicular joint in the X and RZ directions in the body side group were significantly smaller than those in the uplifted group [(0.163±0.120) cm vs. (0.209 ±0.152) cm, P=0.033;0.715°±0.628° vs. 0.910°±0.753°,P=0.011]. The setup errors of acromioclavicular joint in the Y,Z and RZ directions in the body side group were significantly smaller than those in the uplifted group [(0.233±0.135) cm vs. (0.284±0.193) cm, P=0.033;(0.202±0.140) cm vs. (0.252±0.173) cm, P=0.005;0.671°±0.639° vs. 0.885°±0.822°,P=0.023]. The margins of target volume for setup errors were smaller in the X (0.45cm vs. 0.54cm) and Y (0.54cm vs. 0.65cm) directions of the sternoclavicular joint, as well as in the Y (0.59cm vs. 0.78cm) and Z directions (0.53cm vs. 0.72cm) of the acromioclavicular joint in the body side group. Conclusions For lung and esophageal cancer patients requiring supraclavicular irradiation, the body side group yields smaller setup errors and corresponding margins of target volume than the uplifted group. In clinical practice, it is necessary to take comprehensive consideration of the accuracy of radiotherapy and additional radiation of the limbs to select appropriate posture.
		2022 Vol. 31 (3): 272-271 [Abstract] ( 649 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	277	miR-21 regulates the proliferation, invasion and radiosensitivity of cervical cancer HeLa cells by targeting RECK
		Su Yuehui, Zhang Mengzhen
		Objective To explore the effect of miR-21 on cell proliferation, apoptosis, invasion and radiosensitivity of cervical cancer HeLa cells and unravel the underlying mechanism. Methods RT-qPCR assay was used to detect the expression levels of miR-21 in cervical cancer tissues and adjacent non-tumor tissues, normal cervical epithelial cells (H8) and cervical cancer cell lines (HeLa, SiHa, ME180). HeLa cell line with inhibition of miR-21 or knockdown of RECK were constructed. CCK-8, Caspase3/7 live cell apoptosis detection, wound healing test, Transwell invasion, clone formation assay, Western blot and immunofluorescence were performed to detect cell viability, apoptosis, migration, invasion, radiosensitivity and related proteins. The dual luciferase assay verified whether miR-21 targeted RECK. Results MiR-21 level in the cervical cancer tissues was significantly higher than that in its corresponding adjacent non-tumor tissues (P<0.05). The expression levels of miR-21 in cervical cancer cell lines HeLa, SiHa and ME180 were significantly up-regulated compared with those in normal cervical epithelial cells H8(all P<0.05). MiR-21 knockdown significantly inhibited HeLa cell viability, promoted cell apoptosis, reduced radiation tolerance, down-regulated the expression of Cyclin D1, Bcl-2, MMP-2 and MMP-9, and up-regulated the expression P21 and Bax proteins (all P<0.05). miR-21 targeted the 3’-UTR of RECK mRNA and negatively regulated the expression of RECK. Silencing RECK reversed the effects of miR-21 knockdown on HeLa cell apoptosis, migration, invasion and radiosensitivity. Conclusions Inhibiting the expression of miR-21significantly decreases cell viability, induces cell apoptosis, weakens cell migration and invasion capabilities, and enhances the radiosensitivity of HeLa cells. The potential mechanism is closely related to the targeted up-regulation of RECK.
		2022 Vol. 31 (3): 277-283 [Abstract] ( 664 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	288	Research progress on hyperthermia for esophageal cancer
		Yang Yongqiang, Li Xiaole, Zhang Xiangxian, Liang Tiansong, Zheng Yingjuan, Yang Daoke
		Esophageal cancer is a malignant tumor of the digestive system that has a high incidence in China. The traditional treatment methods include surgery, radiotherapy, and chemotherapy, but the long-term efficacy is not good and the side effects are obvious. As a traditional physical therapy, hyperthermia has no significant toxic and side effects. Studies have shown that hyperthermia can increase the sensitivity of esophageal cancer to radiotherapy and chemotherapy, and its combined use in the treatment of esophageal cancer can prolong the survival and improve the quality of life. In addition, the innovation of materials and technologies brings new breakthroughs to tumor hyperthermia.
		2022 Vol. 31 (3): 288-292 [Abstract] ( 617 ) [HTML 1KB] [ PDF 0KB] ( 0 )

Review Articles

	284	Thoracic radiotherapy of limited-stage small cell lung cancer :current situation of dose fractionation
		Zhan Tianyou, Zhou Zongmei
		Thoracic radiotherapy is a major treatment and dose fractionation remains controversial in limited-stage small cell lung cancer. Twice-daily (BID) radiotherapy, as a standard protocol established in prospective studies, is often replaced by other treatment strategies in clinical practice due to the occurrence of side effects and inconvenience. In addition, in inoperable stage Ⅰ small cell lung cancer with negative lymph nodes, stereotactic ablative radiotherapy (SABR) provides a new option for some elderly patients who are expected to be unable to tolerate long-term radiotherapy. The appropriate dose fractionation scheme can both ensure the therapeutic effects and reduce toxic effects. This article reviews the research of limited-stage small cell lung cancer about dose fractionation.
		2022 Vol. 31 (3): 284-292 [Abstract] ( 621 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	293	Research progress on the radioprotective effects of epigallocatechin gallate (EGCG) on normal tissues
		Xie Liwei, Cai Shang, Li Ming, Tian Ye
		Eigallocatechin gallate (EGCG) is the main component of catechins in green tea. It has many biological functions, such as neuroprotective, hypoglycemic, antioxidant, antibacterial, antiviral and anti-tumor effects, etc. It has been widely used in food additives and health products. Radiotherapy is one of the main methods for the treatment of malignant tumors. However, due to its damage to the normal tissues surrounding tumors, the therapeutic dose of radiotherapy is limited and the local control rate of tumors is affected. Therefore, it is of great practical significance to find a kind of radioprotective agent, which is highly effective and non-toxic and has the ability to limit tumor growth. This review summarizes relevant preclinical studies and clinical trial data to reveal the radiation protective mechanism of EGCG,aiming to provide some reference for EGCG to become a potential clinical radiation protection agent.
		2022 Vol. 31 (3): 293-297 [Abstract] ( 636 ) [HTML 1KB] [ PDF 0KB] ( 0 )

	298	Research progress on immune checkpoint inhibitors combined with stereotactic ablative body radiotherapy for advanced non-small cell lung cancer
		Wang Xiaofeng, Bai Hui,Huang Guoding, Liu Feng, Yao Yuan, Liang Jun
		The effect of radiotherapy on anti-tumor immunity is bidirectional, immunotherapy, especially the combination of immune checkpoint inhibitors (ICIs) and radiotherapy, can produce synergistic effects on anti-tumor immunity. Compared with conventional radiotherapy, stereotactic ablative body radiotherapy (SABR) can achieve high-precision and high-dose irradiation on target lesions, and has stronger anti-tumor immune activation effect. At the same time, due to the steep dose gradient, SABR can better protect the surrounding normal tissues, which is an effective means for the rapid control of local lesions in advanced non-small cell lung cancer (NSCLC). ICIs are an important component of standard treatment for advanced NSCLC. There is growing evidence that SABR in combination with ICIs can benefit patients with advanced NSCLC. This article reviews the biological basis and clinical research progress on the combination of these two therapies, aiming to provide reference for the domestic counterparts to better use this new treatment model.
		2022 Vol. 31 (3): 298-302 [Abstract] ( 619 ) [HTML 1KB] [ PDF 0KB] ( 0 )

中华放射肿瘤学杂志

News

More.....

Cooperation unit

友情链接

China Association for
　Science and Technology

Chinese Medical Association

Cancer Hospital of Chinese
　Academy of Medical
　Sciences Department of
　Radiation Oncology

Chinese Anti-Cancer
　Association

Chinese Journal of Lung
　Cancer

Cqvp

CNKI

Wanfang Data

More....