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Interobserver variability in the delineation of the target volume based on supine and prone simulation 3DCT for external-beam partial breast irradiation after breast-conserving surgery
Yu Ting1, Li Yankang2, Li Fengxiang3, Wang Jinzhi3, Wang Wei3, Xu Min3, Zhang Yingjie3, Li Jianbin3
1Tianjin Medical University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300070, China; 2Cheeloo College of Medicine, Shandong University, Ji'nan 250012, China; 3Department of Radiation Oncology, Shandong Cancer Hospital and Institute (Shandong Cancer Hospital), Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan 250117, ChinaYu Ting and Li Yankang are contributed equally to the article
AbstractObjective To explore the interobserver variabilities in the delineation of the target volume using simulation three-dimensional computed tomography (3DCT) between the supine and prone positions for external-beam partial breast irradiation (EB-PBI) after breast-conserving surgery (BCS). Methods Twenty-seven breast cancer patients who were scheduled to receive EB-PBI after BCS from July 2016 to April 2017 were enrolled in this study. All patients underwent axial 3DCT simulation scanning in the supine and prone positions during free breathing. Based on two different simulation 3DCT acquired, the gross target volume (TB) formed by using surgical clips and the clinical target volume (CTV) were delineated by five radiologists using specific guidelines. The following parameters including the target volume, coefficient of variations (COV) and matching degree (MD) were calculated to analyze the interobserver variability. Twenty-seven breast cancer patients who were scheduled to receive EB-PBI after BCS from July 2016 to April 2017 were enrolled in this study. Results Whether in the supine or prone position, the interobserver variabilities for TB and CTV were statistically significant (P<0.001,P=0.001,P<0.001,P=0.001). And the intersection of CTV in the prone position was 5.79 cm3 greater than that in the supine position (P=0.011). The interobserver variability of COVCTV in the prone positionwas significantly lower than that in the supine position (P=0.014). And the interobserver variabilities of MDTBTB and MDTBCTV in the prone positionwere statistically greater than those in the supine position, respectively (P<0.001,P= 0.001). Conclusions When delineating the target volume of EB-PBI in the prone position, the interobsever variability can be reduced compared with that in the supine position. Hence, it is more reasonable to carry out EB-PBI in the prone position in free breathing.
Fund:National Key Research and Development Program (2016YFC0904700);Youth Program of National Natural Science Foundation of China (81703038);Shandong Province Key Research and Development Program (2017GSF18102);Shandong Province Natural Science Foundation (ZR2017PH006)
Corresponding Authors:
Li Jianbin, Email:lijianbin@msn.com
Cite this article:
Yu Ting,Li Yankang,Li Fengxiang et al. Interobserver variability in the delineation of the target volume based on supine and prone simulation 3DCT for external-beam partial breast irradiation after breast-conserving surgery[J]. Chinese Journal of Radiation Oncology, 2020, 29(6): 432-436.
Yu Ting,Li Yankang,Li Fengxiang et al. Interobserver variability in the delineation of the target volume based on supine and prone simulation 3DCT for external-beam partial breast irradiation after breast-conserving surgery[J]. Chinese Journal of Radiation Oncology, 2020, 29(6): 432-436.
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