Research progress on radiotherapy-induced hippocampal damage and cognitive dysfunction in nasopharyngeal carcinoma
Zhou Ling1, Tao Changjuan2, Chen Ming2, Yu Zhonghua3, Chen Yuanyuan2
1The First Clinical Medicine College, Guangdong Medical University, Zhanjiang 524000, China; 2Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences/Zhejiang Cancer Hospital Institute of Cancer and Basic Medicine(IBMC), Chinese Academy of Sciences,Hangzhou 310022, China; 3Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
Abstract：Radiation-induced cognitive dysfunction is a common complication in patients with nasopharyngeal carcinoma after undergoing radiotherapy, which has been proven to be associated with neurogenesis dysfunction, oligodendrocyte loss, vascular damage and abnormal cytokine expression. With the development of medicine, functional magnetic resonance image (fMRI) can detect the early lesions of cognitive dysfunction. Hippocampus-sparing technology and drug therapy (memantine, donepezil and bevacizumab) can mitigate radiation-induced cognitive dysfunction. In this article, the pathogenesis, neuroimaging, radiodosimetry and therapies of radiotherapy-induced cognitive dysfunction in nasopharynal carcinoma patients were reviewed.
Zhou Ling,Tao Changjuan,Chen Ming et al. Research progress on radiotherapy-induced hippocampal damage and cognitive dysfunction in nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2020, 29(11): 1008-1011.
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2020, Vol. 29 
