1The First Clinical Medical College, Guangdong Medical University, Zhanjiang 524000, China; 2Medical research institute, Hangzhou YITU Healthcare Technology Co. Ltd., Hangzhou 330106, China; 3Shanghai Key Laboratory of Artificial Intelligence for Medical Image and Knowledge Graph, Shanghai 200050, China; 4Department of Radiation Oncology, Zhejiang Cancer Hospital / Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Key Laboratory of Radiation Oncology, Zhejiang Provincial Engineering Research Center for Precision Radiotherapy, Hangzhou 310022, China; 5Department of Oncology, the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
Abstract：Objective To analyze the relationship between hematological examination combined with clinical factors and radiation-induced hypothyroidism (HT) in patients with nasopharyngeal carcinoma (NPC). Methods Clinical data of 206 patients with NPC who received radiotherapy in Cancer Hospital of University of Chinese Academy of Sciences between January 2015 to August 2018 were retrospectively analyzed. The correlation between general clinical data, hematological examination and HT was analyzed to establish a hematological prediction model. Results Univariate analysis showed that sex, N-stage, thyroid volume, average dose, V20Gy, V25Gy, V30Gy, V35Gy, V40Gy, V45Gy, fibrinogen content, cholinesterase and neutrophil count were closely associated with the incidence of HT. Multivariate analysis showed that thyroid volume, fibrinogen content and cholinesterase were the independent predictors of HT. Conclusion The combination of sex, N-stage, thyroid volume, dose parameters, fibrinogen content, cholinesterase, neutrophil percentage and neutrophil count can predict the incidence of HT (AUC=0.777).
Zhou Ling,Zhu Chaonan,Chen Jia et al. Early screening of high-risk patients with radiation-induced hypothyroidism in nasopharyngeal carcinoma by hematological examination[J]. Chinese Journal of Radiation Oncology, 2020, 29(9): 739-743.
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