Abstract: 【Purpose/significance】Interdisciplinary research collaboration is an important way to promote research breakthroughs in public health emergencies. Exploring the current situation and characteristics of the collaboration network can help clarify the roles and collaboration modes of different disciplines, identify the shortcomings of the current collaborative network, and provide references for optimizing interdisciplinary research collaboration networks for future public health emergencies. 【Method/process】 Taking COVID-19 as example, this study collected relevant literature data from Web of Science database, annotated the disciplines to which the collaborators belong, constructed interdisciplinary collaboration association matrix, built an overall disciplinary relationship net‑ work with disciplines as nodes, and conducted density analysis, centrality analysis, cohesive subgroup analysis, core-edge analysis. 【Result/conclusion】The interdisciplinary research collaboration involves 59 disciplines, and the overall network has a certain degree of cohesion, but the degree of connection between different disciplines is polarized; the collaboration between three major disciplines of modern medicine (clinical medicine, preventive medicine and public health, and basic medicine) and biology is the mainstream in the collaborative network; comprehensive interdisciplines such as sociology play important bridging role in collaborative networks, pro‑ moting the connection and knowledge communication between different disciplines; there are 8 small groups of disciplines in the col‑ laborative network, and the distribution of close connections within and between disciplines is uneven.【Innovation/limitation】This ar‑ ticle clarifies the structure and characteristics of interdisciplinary research collaboration networks of public health emergencies from the perspective of SNA. In the future, it is still necessary to conduct in-depth analysis of research topics in different disciplinary col‑ laboration modes.