The preservation and restoration are carried out on a piece of archive of Qing dynasty in Nanjing Museum, which has been seriously damaged by worms. After pilot study in earlier period, the museum started to take some technical means to restore, including disinfection and desinsection, strike-off and repair by hand-made, and therefore achieves better effects and makes the archive meet requirements of exhibiting. Besides, the repair paper that used in the restoration is also researched, and the corresponding product is applied in the restoration. On the whole, the preservation and restoration achieves good results.