In order to study the effect of water and nutrient utilization in the Triticum aestivum-Zea mays cropping system, we conducted the experiment of integrated water and fertilizer management in Yuanyang Experimental Station of Crop Water Use,Ministry of Agriculture. The treatments of nitrogen fertilizer were set as base fertilizer, topdressing once and twice. The water conditions were set as irrigation once, twice and three times and the volume of each irrigation was 450 m³ / hm². The results showed that the combination of supplementary irrigation and fertilizer played a positive role in the growth and development of T. aestivum and Z. mays, which increased the spike length of T. aestivum by 0.2 - 0.8 cm, the number of grains per spike by 2 -10, the thousand-grain-weight by 2 -9 g, and the number of panicles by 90 000 -570000 per hectare. For comparison, the same treatment increased the spike length of Z. mays by 0.48 -1.82 cm, the number of grains per row by 2.0 -8.4, the weight of five panicles by 15 - 374 g, and the hundred-kernel-weight by 2.0 -13.0 g. At the same time, the yield of T. aestivum was increased by 9.85% - 37.93% under supplementary irrigation and nitrogen fertilizer topdressing compared with the control. The yield of T. aestivum under supplementary irrigation combined with topdressing treatments was increased by 9.92% -25.66% compared to that only with application of only basal fertilizer, in which the treatment with irrigation for three times and topdressing twice was the optimum. Compared with the treatment of topdressing once, topdressing twice increased the yield by 3.95% -6.11%, in which the treatment with irrigation twice and topdressing twice was the optimum. The yield of Z. mays was increased by 11.05% -46.62%, 18.71% -32.03% and 2.80% -5.42%, respectively, compared with the control, application of basal fertilizer and topdressing once treatment. The total yield of T. aestivum and Z. mays was increased by 10.46% -42.36%, 14.37% -28.87% and 3.34% - 5.75%, respectively, compared with the control, application of basal fertilizer and topdressing once treatment, showing the same tendency with the increase of T. aestivum. The comprehensive water use efficiency of T. aestivum and Z. mays was increased by 0.95 -5.41, 0.56 - 3.81 and 0.35 - 0.67 kg/ m3, respectively, compared with the control, application basal fertilizer and topdressing once treatment. The treatment with irrigation once and topdressing twice was the best. According to our results, the optimum water-saving and yield-increasing treatment was irrigation twice with topdressing twice or irrigation once with topdressing twice.