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Chinese Journal of Radiation Oncology  2019, Vol. 28 Issue (9): 648-651    DOI: 10.3760/cma.j.issn.1004-4221.2019.09.002
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Clinical characteristics,diagnosis and efficacy of primary lymphoepithelial carcinoma of the parotid gland
Wang Huili,Huang Xiaodong,Qu Yuan,Wang Kai,Wu Runye,Zhang Ye,Liu Qingfeng,Zhang Shiping,Xiao Jianping,Yi Junlin,Xu Guozhen,Gao Li,Luo Jingwei
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021,China
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Abstract  Objective To analyze the clinical features,diagnosis and prognosis of patients with primary lymphoepithelial carcinoma of the parotid gland. Methods Clinical data of 13 patients diagnosed with lymphoepithelial carcinoma of the parotid gland in our hospital from 2009 to 2017 were retrospectively analyzed. The median follow-up time was 38.5 months. All patients received radiotherapy after operation. Results Of 13 patients,9 cases were male and 4 female. The median age was 33 years. At the initial diagnosis,9 cases had primary lesions limited to the parotid gland,and 4 cases of lymph node metastases located in Ⅰ b and Ⅱ regions of the neck. According to UICC2010 staging,1 case was classified as stage Ⅰ,1 as stage Ⅱ,6 as stage Ⅲ and 5 as stage Ⅳ, respectively. Eleven surgically pathological specimens were tested with EBER in-situ,and 10 cases were positive for EBER. No patient died in the whole group. The 3-year overall survival rate was 100%. The 3-year progression-free survival rate was 76%. The 3-year local control rate was 92%. The 3-year metastasis-free survival rate was 84%. Conclusions The incidence of lymphoepithelial carcinoma of the parotid gland is relatively low. The pathological features are associated with EB virus. It is prone to present with cervical lymph node metastasis. The possibility of lymph node metastasis of nasopharyngeal carcinoma to the parotid gland should be excluded before treatment. At present, surgery combined with postoperative radiotherapy is the main treatment. The overall survival is favorable. Local recurrence and distant metastasis are the main causes of treatment failure.
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Articles by authors
Wang Huili
Huang Xiaodong
Qu Yuan
Wang Kai
Wu Runye
Zhang Ye
Liu Qingfeng
Zhang Shiping
Xiao Jianping
Yi Junlin
Xu Guozhen
Gao Li
Luo Jingwei
Key wordsLymphoepithelial carcinoma of the parotid gland      EB virus      Treatment outcome     
Received: 09 October 2018     
Fund:National Major Research and Development Program (2016YFC0904600)
Corresponding Authors: Huang Xiaodong,Email:whxd010@163.com;Luo Jingwei,Email:nqluo202@163.com   
Cite this article:   
Wang Huili,Huang Xiaodong,Qu Yuan et al. Clinical characteristics,diagnosis and efficacy of primary lymphoepithelial carcinoma of the parotid gland[J]. Chinese Journal of Radiation Oncology, 2019, 28(9): 648-651.
Wang Huili,Huang Xiaodong,Qu Yuan et al. Clinical characteristics,diagnosis and efficacy of primary lymphoepithelial carcinoma of the parotid gland[J]. Chinese Journal of Radiation Oncology, 2019, 28(9): 648-651.
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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2019.09.002     OR     http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2019/V28/I9/648
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