派姆单抗与纳武单抗治疗晚期恶性肿瘤疗效及安全性初步研究

doi:10.3760/cma.j.issn.1004-4221.2019.09.011

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Abstract Objective To preliminarily compare the efficacy and safety of Pembrolizumab and Nivolumab in the treatment of advanced malignant tumors. Methods Clinical data of 50 patients diagnosed with advanced malignant tumors treated with Pembrolizumab and Nivolumab from January 2017 to August 2018 in our hospital were retrospectively analyzed. All patients were divided into the Pembrolizumab (n=26) and Nivolumab groups (n=24). The incidence of adverse reactions was statistically compared between two groups by using χ² test. The survival analysis was performed by using Kaplan-Meier method. Results The median progression-free survival in the Pembrolizumab group was 213 d, and 146 d in the Nivolumab group (P>0.05). The incidence of aminotransferase elevation and hypothyroidism in the Nivolumab group was significantly higher than that in the Pembrolizumab group (63% vs. 23%,12% vs. 0%, both P<0.05), whereas the incidence of oral mucositis in the Nivolumab group was 0%, significantly lower than 15% in the Pembrolizumab group (P<0.05). The median overall survival time in the Pembrolizumab group was 579d, and 238 d in the Nivolumab group (P>0.05). Conclusion Clinical efficacy does not significantly differ, whereas the incidence of adverse reactions slightly differs between the Pembrolizumab and Nivolumab groups.

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	Hou Lina
	Dina·Suolitiken
	Ren Hua

Key words： Malignant neoplasm/Immunotherapy Treatment outcome Adverse reaction

Received: 28 January 2019

Corresponding Authors: Ran Hua,Email:renhua2009@hotmail.com

Cite this article:

Hou Lina,Dina·Suolitiken,Ren Hua. Preliminary study of efficacy and safety of Pembrolizumab and Nivolumab in treatment of advanced malignant tumors[J]. Chinese Journal of Radiation Oncology, 2019, 28(9): 687-691.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2019.09.011 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2019/V28/I9/687

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