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Chinese Journal of Radiation Oncology  2015, Vol. 24 Issue (6): 611-614    DOI: 10.3760/cma.j.issn.1004-4221.2015.06.002
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A prospective phase II study of consolidation chemotherapy after concurrent chemoradiotherapy for oligometastatic stage IV non-small cell lung cancer
Lyu Jiahua,Li Tao,Liu Li,Li Fang,Li Churong,Song Yanqiong,Wang Qifeng,Wang Junchao
Department of Radiotherapy,Sichuan Cancer Hospital,Chengdu 610041,China
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Abstract  Objective To evaluate the efficacy and safety of consolidation chemotherapy after thoracic radical concurrent chemoradiotherapy for patients with oligometastatic non-small cell lung cancer (NSCLC). Methods Sixty-six NSCLC patients with more than five metastases from 2008 to 2013 were enrolled, and image-guided radiotherapy with conventionally fractionated or hypofractionated doses were performed for these patients. Platinum-based doublets chemotherapy was applied for both concurrent chemoradiotherapy and consolidation chemotherapy. Short-term outcome, adverse reactions, and survival rate were assessed for the patients after treatment. Results Sixty-four patients completed the treatment. The median biologically equivalent dose for planning target volume of thoracic primary tumor lesions was 72 Gy, with a median number of chemotherapy cycles of 4. The Objective response rate for thoracic lesions was 70%. The follow-up rate was 97%. The 1-, 2-, and 3-year overall survival (OS) rates were 72%, 53%, and 31%, respectively, with a median OS time of 25 months;the 1-, 2-, and 3-year progression-free survival (PFS) rates were 56%, 26%, and 7%, respectively, with a median PFS time of 14 months. The incidence of grade 2-3 acute radiation pneumonitis and radiation esophagitis was 1% and 17%, respectively, and the incidence of grade 3-4 decreases in leukocytes, hemoglobin, and platelet count was 39%, 11%, and 16%, respectively. Conclusions Radical radiotherapy combined with concurrent and consolidation chemotherapy for oligometastatic NSCLC can achieve good short-term outcome and long-term survival, with tolerable adverse effects.
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Articles by authors
Lyu Jiahua
Li Tao
Liu Li
Li Fang
Li Churong
Song Yanqiong
Wang Qifeng
Wang Junchao
Key wordsLung neoplasms/radiochemotherapy      Oligometastatic      Treatment outcome      Toxicity     
    
Corresponding Authors: Li Tao,Email:litaoxmf@126.com   
Cite this article:   
Lyu Jiahua,Li Tao,Liu Li et al. A prospective phase II study of consolidation chemotherapy after concurrent chemoradiotherapy for oligometastatic stage IV non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2015, 24(6): 611-614.
Lyu Jiahua,Li Tao,Liu Li et al. A prospective phase II study of consolidation chemotherapy after concurrent chemoradiotherapy for oligometastatic stage IV non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2015, 24(6): 611-614.
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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2015.06.002     OR     http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2015/V24/I6/611
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