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Chinese Journal of Radiation Oncology  2013, Vol. 22 Issue (6): 469-472    DOI: 10.3760/cma.j.issn.1004-4221.2013.06.013
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Incidence of sinusitis and its influential factors in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy
SU Yan-xia,LI Xu,HAO Jun-fang,DONG Wei,YANG Xin-hua,LIU Lan-ping,XU Jin,CAO Xiu-juan,YU Shui
Department of Radiation Oncology,Shandong Tumor Hospital,Shandong Academy of Medical Sciences,Ji′nan University, Ji′nan 250117, China
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Abstract  Objective To investigate the incidence of sinusitis in nasopharyngeal carcinoma (NPC) patients before and after intensity-modulated radiotherapy (IMRT) and analyze the influential factors for incidence of sinusitis after IMRT. Methods A retrospective analysis was performed on 283 NPC patients who received IMRT in our hospital from March 2009 to May 2011. CT or MRI scans were performed before and after IMRT to evaluate the incidence of sinusitis. The influential factors for incidence of sinusitis were analyzed by log-rank univariate analysis and logistic multivariate analysis. Results The incidence rates of sinusitis in patients with T1, T2, T3, and T4 NPC before radiotherapy were 22.6%, 37.5%, 46.8%, and 61.3%, respectively (P=0.002). Among the 155 NPC patients without sinusitis before radiotherapy, the incidence rates of sinusitis at the end of radiotherapy and 1, 3, 6, 9, 12, and 18 months after radiotherapy were 32.9%, 43.2%, 61.3%, 68.4%, 73.5%, 69.7%, and 61.3%, respectively (P=0.000). The univariate analysis showed that T stage, invasion into the nasal cavity, rhinopharynx flush, and radiation dose to the nasopharynx were associated with the incidence of sinusitis in NPC patients after IMRT (P=0.003, 0.006, 0.002, and 0.020). The multivariate analysis showed that T stage, invasion into the nasal cavity, and rhinopharynx flush were the influential factors for incidence of sinusitis in NPC patients after IMRT (P=0.002, 0.002, and 0.000). Conclusions There is a higher incidence of sinusitis with higher T stage among NPC patients before radiotherapy. The incidence of sinusitis grows rapidly within 3 months after IMRT, reaches the peak level at 9 months, and tends to be stable at one year. T stage, invasion into the nasal cavity, and rhinopharynx flush are the influential factors for incidence of sinusitis in NPC patients after IMRT.
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Articles by authors
SU Yan-xia
LI Xu
HAO Jun-fang
DONG Wei
YANG Xin-hua
LIU Lan-ping
XU Jin
CAO Xiu-juan
YU Shui
Key wordsSinusitis      Untoward reaction      Nasopharyngeal neoplasm/intensity-modulated radiotherapy     
Received: 13 June 2013     
Corresponding Authors: HAO Jun-fang, Email:hao-j-f@163.com   
Cite this article:   
SU Yan-xia,LI Xu,HAO Jun-fang et al. Incidence of sinusitis and its influential factors in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy[J]. Chinese Journal of Radiation Oncology, 2013, 22(6): 469-472.
SU Yan-xia,LI Xu,HAO Jun-fang et al. Incidence of sinusitis and its influential factors in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy[J]. Chinese Journal of Radiation Oncology, 2013, 22(6): 469-472.
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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2013.06.013     OR     http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2013/V22/I6/469
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