Abstract： Objective To investigate the short-term complications and cosmetic outcomes of radiotherapy in breast conserving surgery for early-stage breast cancer. Methods A retrospective analysis was performed on clinical data from 30 patients with early-stage breast cancer from 2013 to 2015. All patients underwent breast conserving surgery combined with intraoperative low-energy X-ray radiotherapy. The prescribed dose was 20 Gy at the surface of the applicator. Local complications, radiation injury, and cosmetic outcomes were observed after surgery. Results No grade 3-4 adverse reactions were found in patients. In terms of short-term complications, four patients (13%) had seroma, two of whom needed suction treatment;three patients (10%) had grade 1-2 skin erythema. Half of the patients had excellent cosmetic outcomes. None of the patients had local recurrence or distant metastasis. Conclusions Intraoperative low-energy X-ray radiotherapy is safe and feasible in breast conserving surgery for breast cancer. It can be considered as an optional approach for tumor bed boost in some patients with early-stage low-risk breast cancer.
Xiong Ying,Zhou Wei,Huang Linping et al. Safety and feasibility of low-energy X-ray radiotherapy in breast conserving surgery for early-stage breast cancer[J]. Chinese Journal of Radiation Oncology, 2017, 26(3): 307-309.
[1] Vaidya JS,Baum M,Tobias JS,et al. Long-term results of targeted intraoperative radiotherapy (Targit) boost during breast-conserving surgery[J].Int J Radiat Oncol Biol Phys,2011,81(4):1091-1097.DOI:10.1016/j.ijrobp.2010.07.1996. [2] Wenz F,Welzel G,Blank E,et al. Intraoperative radiotherapy as a boost during breast-conserving surgery using low-kilovoltage X-rays:the first 5 years of experience with a novel approach[J].Int J Radiat Oncol Biol Phys, 2010 Aug 1;77(5):1309-1314. DOI:10.1016/j.ijrobp.2009.06.085. [3] Vaidya JS,Wenz F,Bulsara M,et al. Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer:5-year results for local control and overall survival from the TARGIT-a randomised trial[J].Lancet,2014,383(9917):603-613.DOI:10.1016/S0140-6736(13)61950-9. [4] Vaidya JS,Baum M,Tobias JS,et al. Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial):an international,prospective,randomised,non-inferiority phase 3 trial[J].Lancet,2010,376(9735):91-102.DOI:10.1016/S0140-6736(10)60837-9. [5] Veronesi U,Orecchia R,Maisonneuve P,et al. Intraoperativeradiotherapy versus external radiotherapy for early breast cancer (ELIOT):a randomised controlled equivalence trial[J]. Lancet Oncol,2013,14(13):1269-1277.DOI:10.1016/S1470-2045(13)70497-2. [6] Vaidya JS,Tobias JS,Baum M,et al. Intraoperative radiotherapyfor breast cancer[J].Lancet Oncol,2004,5(3):165-173. [7] American Society of Breast Surgeons. ASBS consensus statement for accelerated partial breast irradiation[J/OL][2016-09-10].https://www.breastsurgeons.org/statements/ PDF_Statements/APBI.pdf. Updated August 15,2011. [8] Smith BD, Arthur DW, Buchholz TA,et al. Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO)[J].J Am Coll Surg,2009,209(2):269-277.DOI:10.1016/j.jamcollsurg.2009.02.066. [9] Shah C, Vicini F, Wazer DE, et al. The American Brachytherapy Society consensus statement for accelerated partial breast irradiation[J].Brachytherapy,2013,12(4):267-277.DOI:10.1016/j.brachy.2013.02.001. [10] Blank E,Kraus-Tiefenbacher U,Welzel U,et al.“Single-center long-term follow-up after intraoperative radiotherapy as a boost during breast-conserving surgery using low-kilovoltage X-rays,”[J].Ann Surg Oncol,2010,17(3):352-358.DOI:10.1245/s10434-010-1265-z. [11] Benda RK,Yasuda G,Sethi A,et al. Breast boost:are we missing the target?[J].Cancer,2003,97(4):905-910. [12] Ruano-Ravina A,Cantero-Munoz P,Eraso-Urien A.Efficacy and safety of intraoperative radiotherapy in breast cancer:a systematic review[J].Cancer Lett,2011,313(1):15-25.DOI:10.1016/j.canlet.2011.08.020. [13] Belletti B,Vaidya JS,D’Andrea S,et al. Targeted intraoperative radiotherapy (TARGIT) impairs surgical wound-stimulated breast cancer cell proliferation and invasion[J].Clin Cancer Res,2008,14(5):1325-1332.DOI:10.1158/1078-0432.CCR-07-4453. [14] Veronesi U,Orecchia R,Luini A,et al. Full-dose intraoperative radiotherapy with electrons during breast-conserving surgery:experience with 590 cases[J].Ann Surg,2005,242(1):101-106. [15] Ivaldi GB,Leonardi MC,Orecchia R,et al. Preliminary results of electronintraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women[J].Int J Radiat Oncol Biol Phys,2008,72(2):485-493. [16] 周士福,时伟锋,孟东,等.早期乳腺癌保乳手术术中放疗59例[J].中华普通外科杂志,2011,26(12):981-984.DOI:10.3760/cma.j.issn.1007-631X.2011.12.003. Zhou SF,Shi WF,Meng D,et al. Breast conserving surgery for early breast cancer:a report of 59 cases[J].Chin J Gene Surg,2011,26(12):981-984.DOI:10.3760/cma.j.issn.1007-631X.2011.12.003.
2017, Vol. 26 
