Analysis of the registration deviation between CT and CBCT images with different breathing rates and motion amplitudes in the state of free breathing
Wei Xing1, Xu Xin1, Bai Long2, Gong Pan2, Zhong Renming2
1 Division of Radio-chemotherapy for Oncology,West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education,Chengdu 610041, China; 2 Department of Radiotherapy Cancer Center, West China Hospital Sichuan University, Chengdu 610041, China
Abstract：Objective To quantify the registration deviation between CT and cone-beam computed tomography (CBCT) images with different breathing rates and motion amplitudes under free breathing state. Methods Using the QUASAR respiratory motion phantom, breathing rate and motion amplitude in the superior-inferior (SI) direction were changed to simulate free breathing motion under different states. The CT and CBCT images were acquired under different breathing rates and motion amplitudes, and static states, then the registration errors between CT and CBCT images and CT target volume were obtained and subject to quantitative analysis. Results Using the static CT image as a reference, the changes in breathing rate exerted no significant effect on the registration error when the motion amplitude was constant. When the motion amplitude was 0.5, 1.0, 2.0, and 3.0 cm, the average registration errors were (0.213±0.020), (0.351±0.009), (0.654±0.010), and (0.972±0.022) cm, respectively. When the motion amplitude was 0.5 and 1.0 cm, the CT target volume varied from -16.92% to 18.78%. When the motion amplitude was 2.0 and 3.0 cm, the CT target volume changed from -16.44% to 81.78%. Conclusions The changes in breathing rate under free-breathing state has no significant effect on the registration error between CBCT and CT images. When the motion amplitude is 0.5 and 1.0 cm, the CT target volume changes and the registration errors are small. When themotion amplitude is 2.0 and 3.0 cm, the registration errors exceed 0.5 cm and the CT target volume changes may exceed 20%.
Wei Xing,Xu Xin,Bai Long et al. Analysis of the registration deviation between CT and CBCT images with different breathing rates and motion amplitudes in the state of free breathing[J]. Chinese Journal of Radiation Oncology, 2022, 31(7): 628-632.
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