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放疗诱发淋巴细胞减少的影响因素及预后的研究进展
孙广毅, 王淑莲
国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科 100021
Research progress on the influencing factors and prognosis of radiation-induced lymphopenia
Sun Guangyi, Wang Shulian
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Abstract：Lymphocyte-led immunity plays an important role in the occurrence and development of tumors. It has been found that radiotherapy can induce lymphopenia in patients with solid tumors, and radiotherapy-induced lymphopenia (RIL) might be caused by the irradiation of circulating blood. The sensitivity to irradiation differs among different subtypes of lymphocytes. RIL can be affected by radiation fractionation, technique and volume. Meanwhile, it has been proven that RIL can significantly reduce the survival of patients with multiple solid tumors. In this article, relevant researches were reviewed, aiming to advance clinical treatment decisions and optimize radiotherapy protocols.
Sun Guangyi,Wang Shulian. Research progress on the influencing factors and prognosis of radiation-induced lymphopenia[J]. Chinese Journal of Radiation Oncology, 2021, 30(7): 753-756.
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