[an error occurred while processing this directive]|[an error occurred while processing this directive]
放肤膏对比比亚芬防治鼻咽癌放射性皮肤损伤的初步疗效观察及护理
史可夫, 祁丽萍, 周丹, 冯惠霞
中山大学肿瘤防治中心放疗科,广州 510060
Observation of preliminary efficacy and nursing care of skin relief cream and Biafine for radiation-induced skin damage in patients with nasopharyngeal carcinoma
Shi Kefu, Qi Liping, Zhou Dan, Feng Huixia
Department of Radiation Oncology,Sun Yat-sen University Cancer Center,Guangzhou 510060,China
Abstract：Objective To compare the preliminary efficacy and nursing care of radioprotective agent skin relief cream and Biafine for the prevention and treatment of neck radiation-induced skin damage in patients with nasopharyngeal carcinoma. Methods Sixty-seven nasopharyngeal carcinoma patients initially treated with intensity-modulated radiotherapy in Sun Yat-sen University Cancer Prevention and Control Center from 2016 to 2017 were recruited and assigned into the control (n=36) and experimental groups (n=31). In the control group, Biafine was applied to the skin in the radiation field and radioprotective agent skin relief cream was applied in the experimental group. The degree of radiation skin injury and adverse reactions were statistically compared between two groups. Results No grade IV radiation-induced skin damage occurred in two groups. The incidence rates of grade 1, 2 and 3 radiation-induced skin damage in the experimental group were 45%,42% and 13%, and 17%,64% and 19% in the control group, respectively (P=0.04). Radioprotective agent skin relief cream could control the radiation-induced skin injury within grade Ⅱ and significantly increase the proportion of grade I skin injury. Conclusion Medical radioprotective agent is superior to Biafine in the prevention and treatment of radiation-induced skin damage in patients with nasopharyngeal carcinoma.
Shi Kefu,Qi Liping,Zhou Dan et al. Observation of preliminary efficacy and nursing care of skin relief cream and Biafine for radiation-induced skin damage in patients with nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2019, 28(10): 728-730.
[1] 蓝晓雯,林潇,何海燕,等. 医用射线防护剂对比三乙醇胺乳膏防治乳腺癌改良根治术后放疗皮肤损伤临床观察[J]. 中华放射肿瘤学杂志,2018,27(9):818-821. DOI:10.3760/cma.j.issn.1004-4221.2018.09.006. Lan XW,Lin Xiao,He Haiyan,et al. Clinical effect of medical radiation protective ointment compared with trolamine cream to prevent acute radiation-induced skin injury in breast cancer patients undergoing radiotherapy after modified radical mastectomy[J]. Chin J Radiat Oncol,2018,27(9):818-821. DOI:10.3760/cma.j.issn.1004-4221.2018.09.006. [2] 王丹惠. 强化营养护理干预对放疗患者放射性皮炎的预防效果[J]. 实用临床医学杂志,2016,20(22):169-170. Wang DH. The effect of intensive nutrition nursing intervention on the prevention of radiation dermatitis in patients with radiotherapy[J]. J Clin Med Pract,2016,20(22):169-170. [3] Zheng Y,Han F,Xiao W,et al. Analysis of late toxicity in nasopharyngeal carcinoma patients treated with intensity modulated radiation therapy[J]. Radiat Oncol,2015,10(1):17. DOI:10.1186/s13014-014-0326-z. [4] 严凌花,刘心慧,石秀芳,等. 奥克喷防治鼻咽癌急性皮肤黏膜放射性损伤效果观察[J]. 护理研究,2016,30(2):468-470. DOI:10.3969/j.issn.1009-6493.2016.04.027. Yan LH,Liu XH,Shi XF,et al. Effect observation on oak spray in treatment and prevention of acute skin and mucosa radiation injury[J]. Chin Nur Res,2016,30(2):468-470. DOI:10.3969/j.issn.1009-6493.2016.04.027. [5] 龙小庆,王继生,贾霖,等. 三乙醇胺防治放射性皮炎有效性的 Meta分析及 GRADE证据质量评价[J]. 中国药房,2019,30(2):258-283. DOI:10.6039/j.issn.1001-0408.2019.02.24. Long XQ,Wang JS,Jia L,et al. Meta-analysis of the effectiveness of trolamine for preventing and treating radiation dermatitis and quality evaluation of GRADE evidence[J]. China Pharmacy,2019,30(2):258-283. DOI:10.6039/j.issn.1001-0408.2019.02.24. [6] 节阳华,艾兰·塔拉干,马全海,等. 湿润烧伤膏联合比亚芬防治乳腺癌术后放射性皮肤损伤的临床观察[J]. 广州中医药大学学报,2019,3(36):341-344. DOI:10.13359/j.cnki.gzxbtcm.2019.03.009. Jie YH,Ailan·TLG,Ma QH,et al. Clinical observation of moist exposed burn ointment combined with Biafine cream in preventing and treating radiation-induced skin injury of postoperative breast cancer patients[J]. J Guangzhou Univ Tradit Chin Med,2019,3(36):341-344. DOI:10.13359/j.cnki.gzxbtcm.2019.03.009. [7] 林刘文,黄群峰,陈国章,等. 医用射线防护剂对鼻咽癌放射性皮肤损伤的防护作用[J]. 广东医学,2013(22):3495-3497. DOI:10.1382/j.cnki,gdyx,2013.22.062. Lin LW,Huang QF,Chen GZ,et al. Clinical effect of medical radiation protective ointment to ptotecct acute radiation-induced skin injury in nasopharyngeal carcinoma[J]. Guangdong Med J,2013(22):3495-3497. DOI:10.1382/j.cnki,gdyx,2013.22.062.
2019, Vol. 28 
