Clinical effect of medical radiation protective ointment compared with trolamine cream to prevent acute radiation-induced skin injury in breast cancer patients undergoing radiotherapy after modified radical mastectomy
Lan Xiaowen, Lin Xiao, He Haiyan, Chen Jie, Zhu Xiaohua, Tan Yuting, Xue Weiping, Huang Xiaobo
Department of Radiation Oncology (Lan XW,Chen J,Zhu XH,Xue WP,Huang XB),Breast Tumor Center (Lin X,He HY,Tan YT,Huang XB),Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,China
Abstract：Objective To access the clinical effect of medical radiation protective ointment compared with trolamine cream to prevent acute radiation-induced skin injury in breast cancer patients undergoing radiotherapy after modified radical mastectomy. Methods Between February 2017 and February 2018,a total of 120 stage T1-4N1-3M0 eligible patients received intensity modulated radiation therapy were enrolled and matches into two groups:study group (60 cases) was administered medical radiation protective ointment from the first irradiation fraction,and control group (60 cases) received trolamine cream. When 3 grade reaction was observed,patients in control group start to administer medical radiation protective ointment until a month after radiation. Results The occurrence rate of acute breast dermal radiation reaction was 100%.Most patients in study group only underwent 1 grade radiation reaction (82%),while 2 and 3 grade radiation reaction (47% and 13%) in control group were common (P=0.000).Both pruritic degree and pain degree were higher in control group compared with study group (both P=0.000).In study group,the occurrence of 2 grade acute radiation-induced skin injury was obviously later than in control group with significant difference (P=0.000).Patients observed with 3 grade reaction relieved to certain reaction after administering medical radiation protective ointment. Conclusions Medical radiation protective ointment can effectively both alleviate and delay acute radiation-induced skin injury compared with trolamine cream. It also has therapeutic effect on 3 grade radiation reaction.
Lan Xiaowen,Lin Xiao,He Haiyan et al. Clinical effect of medical radiation protective ointment compared with trolamine cream to prevent acute radiation-induced skin injury in breast cancer patients undergoing radiotherapy after modified radical mastectomy[J]. Chinese Journal of Radiation Oncology, 2018, 27(9): 818-821.
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2018, Vol. 27 
