Early evaluation of tumor radiation response by medical imaging
Zhang Nasha,Zhu Hui,Zhu Jian,Yu Jinming
Medical College of Shandong University,Ji’nan 250117,China (Zhang NS);First Department of Special Medicine (Zhang NS,Zhu H,Yu JM),Department of Physics (Zhu J),Shandong Cancer Hospital,Ji’nan 250117,China
Abstract：Response evaluation criteria in solid tumors is widely used for assessing tumor response to radiotherapy in clinical practice. However, it is clearly insufficient. Currently there is no ideal method for early evaluation of tumor radiation response. This paper reviews studies on early evaluation of radiotherapy efficacy by positron emission tomography-computed tomography (CT), magnetic resonance imaging, and CT. This paper also further explores the necessity and feasibility of CT values of megavoltage CT scans in early evaluation of the radiosensitivity of tumor during tomotherapy.
Zhang Nasha,Zhu Hui,Zhu Jian et al. Early evaluation of tumor radiation response by medical imaging[J]. Chinese Journal of Radiation Oncology, 2017, 26(2): 243-246.
[1] Wang JB,Wong KK,Piert M,et al. Metabolic response assessment with 18F-FDG PET-CT:inter-method comparison and prognostic significance for patients with non-small cell lung cancer[J].J Raidat Oncol,2015,4(3):249-256.DOI:10.1007/s13566-015-0184-9. [2] Yang YQ,Yang ZQ,Han AQ,et al. Prediction of the outcome of definitive chemoradiation by decrease in F-18 FDG uptake in nonsurgical esophageal squamous cell cancer[J].Clin Nucl Med,2011,36(10):860-866.DOI:10.1097/RLU.0b013e318219b0c0. [3] Allen-Auerbach M,Weber WA.Measuring response with FDG-PET:methodological aspects[J].Oncologist,2009,14(4):369-377.DOI:10.1634/theoncologist.2008-0119. [4] Stahl A,Ott K,Schwaiger M,et al. Comparison of different SUV-based methods for monitoring cytotoxic therapy with FDG PET[J].Eur J Nucl Med Mol Imaging,2004,31(11):1471-1478.DOI:10.1007/s00259-004-1626-6. [5] Rafat M,Ali R,Graves EE.Imaging radiation response in tumor and normal tissue[J].Am J Nucl Med Mol Imaging,2015,5(4):317-332. [6] Everitt SJ,Ball DL,Hicks RJ,et al. Differential 18F-FDG and 18F-FLT uptake on serial PET-CT imaging before and during definitive chemoradiation for non-small cell lung cancer[J].J Nucl Med,2014,55(7):1069-1074.DOI:10.2967/jnumed.113.131631. [7] Trigonis I,Koh PK,Taylor B,et al. Early reduction in tumour[18F]fluorothymidine (FLT) uptake in patients with non-small cell lung cancer (NSCLC) treated with radiotherapy alone[J].Eur J Nucl Med Mol Imaging,2014,41(4):682-693.DOI:10.1007/s00259-013-2632-3. [8] Everitt S,Hicks RJ,Ball D,et al. Imaging cellular proliferation during chemo-radiotherapy:a pilot study of serial 18F-FLT positron emission tomography/computed tomography imaging for non-small-cell lung cancer[J].Int J Radiat Oncol Biol Phys,2009,75(4):1098-1104.DOI:10.1016/j.ijrobp.2008.12.039. [9] Porter AG,Jnicke RU.Emerging roles of caspase-3 in apoptosis[J].Cell Death Differ,1999,6(2):99-104.DOI:10.1038/sj.cdd.4400476. [10] Allen AM,Ben-Ami M,Reshef A,et al. Assessment of response of brain metastases to radiotherapy by PET imaging of apoptosis with 18F-ML-10[J].Eur J Nucl Med Mol Imaging,2012,39(9):1400-1408.DOI:10.1007/s00259-012-2150-8. [11] de Lussanet QG,Backes WH,Griffioen AW,et al. Dynamic contrast-enhanced magnetic resonance imaging of radiation therapy-induced microcirculation changes in rectal cancer[J].Int J Radiat Oncol Biol Phys,2005,63(5):1309-1315.DOI:10.1016/j.ijrobp.2005.04.052. [12] Feng CL,Gao PY,Qiu XG,et al. Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic resonance imaging[J].Chin J Cancer Res,2015,27(3):231-238.DOI:10.3978/j.issn.1000-9604.2015.05.06. [13] Spratt DE,Arevalo-Perez J,Leeman JE,et al. Early magnetic resonance imaging biomarkers to predict local control after high dose stereotactic body radiotherapy for patients with sarcoma spine metastases[J].Spine J,2016,16(3):291-298.DOI:10.1016/j.spinee.2015.08.041. [14] Zahra MA,Tan LT,Priest AN,et al. Semiquantitative and quantitative dynamic contrast-enhanced magnetic resonance imaging measurements predict radiation response in cervix cancer[J].Int J Radiat Oncol Biol Phys,2009,74(3):766-773.DOI:10.1016/j.ijrobp.2008.08.023. [15] Moffat BA,Chenevert TL,Lawrence TS,et al. Functional diffusion map:a noninvasive MRI biomarker for early stratification of clinical brain tumor response[J].Proc Natl Acad Sci USA,2005,102(15):5524-5529.DOI:10.1073/pnas.0501532102. [16] Birlik B,Obuz F,Elibol FD,et al. Diffusion-weighted MRI and MR-volumetry-in the evaluation of tumor response after preoperative chemoradiotherapy in patients with locally advanced rectal cancer[J].Magn Reson Imaging,2015,33(2):201-212.DOI:10.1016/j.mri.2014.08.041. [17] Chen X,Zhang J,Dalah E,et al. Change of CT number during the course of chemoradiation therapy for pancreatic cancer[J].Med Phys,2015,42(6):3328.DOI:10.1118/1.4924354. [18] Yang C,Liu F,Tai A,et al. Characterization of radiation induced CT number changes in tumor and normal lung during radiation therapy for lung cancer[J].Med Phys,2014,41(6):200.DOI:10.1118/1.4888243. [19] Zhao BS,Schwartz LH,Larson SM.Imaging surrogates of tumor response to therapy:anatomic and functional biomarkers[J].J Nucl Med,2009,50(2):239-249.DOI:10.2967/jnumed.108.056655. [20] Feng M,Yang CG,Chen XJ,et al. Computed tomography number changes observed during computed tomography-guided radiation therapy for head and neck cancer[J].Int J Radiat Oncol Biol Phys,2015,91(5):1041-1047.DOI:10.1016/j.ijrobp.2014.12.057. [21] Mahon R,Tennyson N,Weiss E,et al. Change in mean CT Intensity of lung tumors during radiation treatment[J].Med Phys,2015,42(6):3328.DOI:10.1118/1.4924353. [22] Mayer R,Stanton K,Kleinberg L,et al. CT number distribution and its association with local control and as a marker of lung tumor response to radiation[J].Radiat Oncol Investig,1998,6(6):281-288.DOI:10.1002/(SICI)1520-6823(1998)6:6<281::AID-ROI6>3.0.CO;2-H. [23] Diot Q,Kavanagh B,Schefter T,et al. Regional normal lung tissue density changes in patients treated with stereotactic body radiation therapy for lung tumors[J].Int J Radiat Oncol Biol Phys,2012,84(4):1024-1030.DOI:10.1016/j.ijrobp.2011.11.080. [24] Kahán Z,Csenki M,Varga Z,et al. The risk of early and late lung sequelae after conformal radiotherapy in breast cancer patients[J].Int J Radiat Oncol Biol Phys,2007,68(3):673-681.DOI:10.1016/j.ijrobp.2006.12.016. [25] De Ruysscher D,Sharifi H,Defraene G,et al. Quantification of radiation-induced lung damage with CT scans:the possible benefit for radiogenomics[J].Acta Oncol,2013,52(7):1405-1410.DOI:0.3109/0284186X.2013.813074. [26] 张磊,程品晶,单国平,等.螺旋断层放射治疗的研究进展[J].实用医学杂志,2015,31(12):2056-2058.DOI:10.3969/j.issn.1006-5725.2015.12.052. Zhang L,Cheng JJ,Shan GP,et al. Development of helical TomoTherapy[J].J Pract Med,2015,31(12):2056-2058.DOI:10.3969/j.issn.1006-5725.2015.12.052.
2017, Vol. 26 
