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中华放射肿瘤学杂志
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中华放射肿瘤学杂志  2016, Vol. 25 Issue (6): 552-556    DOI: 10.3760/cma.j.issn.1004-4221.2016.06.003
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应用短暂味觉刺激后DWI评价放疗前后涎腺功能的初步研究
徐亮,田野,徐莹莹,钱建军,朱雅群,范秋虹,张力元,赵丹蕾,沈钧康
215004 苏州大学附属第二医院放射科(徐亮、赵丹蕾、沈钧康),放疗科(田野、徐莹莹、钱建军、朱雅群、范秋虹、张力元)
Value of diffusion-weighted imaging after transient taste stimulation in evaluation of salivary gland function before and after radiotherapy:a preliminary study
Xu Liang,Tian Ye,Xu Yingying,Qian Jianjun,Zu Yaqun,Fan Qiuhong,Zhang Liyuan,Zhao Danlei,Shen Junkang
Department of Radiology,Second Affiliated Hospital,Soochow University,Suzhou 215004,China
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摘要 目的 探讨短暂味觉刺激后DWI评价鼻咽癌患者放疗前后主涎腺功能改变的价值,分析ADC值与其他评价方法间的相关性。方法 2010—2014年对30例鼻咽癌患者在放疗前后行味觉刺激后动态DWI检查,分析各涎腺ADC值变化曲线特点。配对t检验放疗前后ADC峰值时间、静息ADC值、刺激后最大ADC值、最大ADC增加率差异。Pearson分析各涎腺ADC值与唾液流率、放疗后各涎腺ADC值与CTCAE分级和可视模拟分级法评分的相关性。结果 放疗前后各涎腺的ADC值均于味觉刺激后第1次扫描(30 s)达峰值。放疗后各涎腺静息ADC值、刺激后最大ADC值均显著高于放疗前(P值分别为0.000、0.000、0.000和0.001、0.000、0.000)。放疗前后各涎腺刺激后最大ADC值增加率差异无统计学意义(P值分别为0.213、0.122、0.839)。放疗前颌下腺静息ADC值与全腺体唾液流率间有相关性(r=0.364,P=0.048)。结论 短暂味觉刺激后DWI可以有效显示鼻咽癌放疗后各涎腺ADC值动态变化特点及与放疗前差异,在评价涎腺功能减退及动态监测涎腺功能变化方面具有很大潜力。
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徐亮
田野
徐莹莹
钱建军
朱雅群
范秋虹
张力元
赵丹蕾
沈钧康
关键词 味觉刺激 涎腺 弥散加权成像 磁共振成像 鼻咽肿瘤/放射治疗 口干症
 
  基金项目:江苏省临床医学科技专项(BL2014040)苏州市科技发展计划(SYSD2011096)    
AbstractObjective To investigate the value of diffusion-weighted imaging (DWI) after transient taste stimulation in evaluating salivary gland function before and after radiotherapy (RT), as well as the correlation between apparent diffusion coefficient (ADC) and other evaluation methods. Methods A total of 30 patients with nasopharyngeal carcinoma (NPC) underwent dynamic DWI after taste stimulation before and after RT from 2010 to 2014. The characteristics of ADC changing curves for each salivary gland were analyzed. The paired t-test was used for comparison of the time to ADC peak, resting ADC, maximum ADC after stimulation, and maximum ADC increase rate. Pearson correlation analysis was used to investigate the correlation between ADC of the salivary gland and salivary flow rate, as well as the correlation of ADC of the salivary gland after RT with Common Terminology Criteria for Adverse Events (CTCAE) grade and visual analog scale (VAS) score. Results Before and after RT, ADCs of each salivary gland reached the peak value at the first scan after taste stimulation (30 s). The resting ADCs and maximum ADC after stimulation of each salivary gland increased significantly after RT (P=0.000,0.000,0.000 and 0.001.0.000,0.000), while the maximum ADC increase rate after stimulation showed no significant differences between the salivary glands (P=0.213, 0.122, and 0.839). Before RT, the resting ADC of submandibular gland was positively correlated with salivary flow rate of all glands (r=0.364, P=0.048). Conclusions DWI after transient taste stimulation can effectively show the dynamic changes in ADCs of all salivary glands after RT for NPC and has a great potential in evaluating salivary hypofunction and dynamically monitoring functional changes of the salivary glands.
Key wordsGustatory stimulation    Salivary glands    Diffusion weighted imaging    Magnetic resonance imaging    nasopharyngeal neoplasms/radiotherapy    Xerostomia   
收稿日期: 2014-12-09     
基金资助:江苏省临床医学科技专项(BL2014040);苏州市科技发展计划(SYSD2011096)
通讯作者: 田野,Email:dryetian@hotmail.com   
引用本文:   
徐亮,田野,徐莹莹等. 应用短暂味觉刺激后DWI评价放疗前后涎腺功能的初步研究[J]. 中华放射肿瘤学杂志, 2016, 25(6): 552-556.
Xu Liang,Tian Ye,Xu Yingying et al. Value of diffusion-weighted imaging after transient taste stimulation in evaluation of salivary gland function before and after radiotherapy:a preliminary study[J]. Chinese Journal of Radiation Oncology, 2016, 25(6): 552-556.
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