Abstract：Objective To evaluate the effects of dose-volume parameters on acute radiation-induced left ventricular diastolic and systolic function damages in patients with thoracic cancer after radiotherapy. Methods A total of 109 patients with thoracic cancer admitted to our hospital from 2008 to 2012 were included in the study. Left ventricular function was assessed by Common Terminology Criteria for Adverse Events Version 3.0. The effects of dose-volume parameters on left ventricular damage were analyzed. Results Left ventricular diastolic and systolic function damages occurred in 15 patients (13.8%) and 24 patients (22.0%), respectively. Ejection fraction and fractional shortening showed no significant correlation with dose-volume parameters, while E/A ratio had a significant correlation with many dose-volume parameters. The volumes of left ventricle receiving radiation of ≥50 Gy and ≥55 Gy (V50 and V55) were significantly higher in patients with acute radiation-induced left ventricular diastolic function damage than in those without left ventricular damage (P=0.026;P=0.034). V50 was the independent influential factor for acute radiation-induced left ventricular diastolic function damage (P=0.025). Compared with those before radiotherapy, the average E/A ratios at 3 months after radiotherapy began in patients with V50 of ≥1.78% and V50 of<1.78% were reduced by 25.6% and 11.8%, respectively. Conclusions Radiotherapy for thoracic cancer can lead to left ventricular diastolic and systolic function damages. V50 is the independent influential factor for acute radiation-induced left ventricular diastolic function damage, while there is no correlation between systolic function indices and dose-volume parameters. For patients with V50 of ≥1.78%, the incidence of diastolic function damage increases significantly, and E/A ratio decreases significantly.
Wang Jun,Long Shujing,Jing Shaowu et al. Analysis of dose-volume factors for acute left ventricular damage in patients with thoracic cancer after radiotherapy[J]. Chinese Journal of Radiation Oncology, 2014, 23(4): 326-330.
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