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胶质瘤干细胞放射抗拒和放射增敏蛋白质组学研究进展
张姗姗1, 沈云天1, 范秋虹1, 田野1, 黄强2
1苏州大学附属第二医院放疗科 215004; 2苏州大学附属第二医院神经外科 215004
Research progress on radiation-resistant and radiation-sensitive proteomics in glioma stem cells
Zhang Shanshan1, Shen Yuntian1, Fan Qiuhong1, Tian Ye1, Huang Qiang2
1Department of Radiotherapy,Second Affiliated Hospital of Soochow University,Suzhou 215004,China; 2Department of Neurosurgery,Second Affiliated Hospital of Soochow University,Suzhou 215004,China
Abstract：After multidisciplinary treatment including radiotherapy, the median survival of patients with glioblastoma multiforme (GBM) remains approximately 1 year. The heterogeneity of the genome and proteome of glioblastoma stem cells (GSC) is the fundamental factor affecting the prognosis. Proteomics-based sensitization of key radioresistance proteins is expected to improve the prognosis of GBM patients. In this article, literature review was conducted from PubMed and other databases in the previous 10 years to systematically discuss the research progress on various commonly used protein quantitative techniques, tools for data processing analysis and the application in radioresistance and radiosensitization of GSCs.
Zhang Shanshan,Shen Yuntian,Fan Qiuhong et al. Research progress on radiation-resistant and radiation-sensitive proteomics in glioma stem cells[J]. Chinese Journal of Radiation Oncology, 2020, 29(2): 150-153.
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2020, Vol. 29 
