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非小细胞肺癌脑转移全脑放疗应用的变革及发展
杨斯苒, 肖建平
国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科 100021
The application of whole-brain radiotherapy for non-small cell lung cancer with brain metastases:evolution and revolution
Yang Siran, Xiao Jianping
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021,China
Abstract：Whole brain radiotherapy (WBRT) was widely used clinically as the standard therapy for brain metastases (BM). With the development of radiotherapy technology and systemic therapies,the non-small cell lung cancer (NSCLC) patients have prolonged local control rate and median survival time,meanwhile post-radiotherapy intracranial toxicities often lead to serious impacts on the quality of life and neurocognitive function. Therefore,the role WBRT played should have been reevaluated. The purpose of this review is to analyze the clinical application value of WBRT in the context of new treatments for NSCLC with BM,and to predict the main developing directions of WBRT in the future.
Yang Siran,Xiao Jianping. The application of whole-brain radiotherapy for non-small cell lung cancer with brain metastases:evolution and revolution[J]. Chinese Journal of Radiation Oncology, 2019, 28(10): 784-791.
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2019, Vol. 28 
