[an error occurred while processing this directive]|[an error occurred while processing this directive]
四维锥形束CT在肺癌放疗中的应用
杨旭, 梁军
国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科 100021
The application of four-dimensional cone-beam CT in radiotherapy for lung cancer
Yang Xu,Liang Jun
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021,China
Abstract: Radiotherapy is an indispensable treatment of lung cancer. However, movement of lung cancer brings challenges to precise radiotherapy. Four-dimensional cone-beam CT is a four-dimensional imaging technique, which can demonstrate the tumor trajectory to improve the accuracy of radiotherapy.In this article, the research status and development tendency of four-dimentional cone-beam CT in terms ofmeasuring and correcting set-up errors, observing variability of tumor postion and movement, guiding delineation of target volumes as well as calculating radiation dose were retrospectively reviewed.
Yang Xu,Liang Jun. The application of four-dimensional cone-beam CT in radiotherapy for lung cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(8): 621-624.
[1] Lee S,Yan G,Lu B,et al. Impact of scanning parameters and breathing patterns on image quality and accuracy of tumor motion reconstruction in 4D CBCT:a phantom study[J]. J Appl Clin Med Phys,2015,16(1):195-212. DOI:10.1120/jacmp.v16i6.5620. [2] Dang J,Gu X,Pan T,et al. A pilot evaluation of a 4-dimensional cone-beam computed tomographic scheme based on simultaneous motion estimation and image reconstruction[J]. Int J Radiat Oncol Biol Phys,2015,91(2):410-418. DOI:10.1016/j.ijrobp.2014.10.029. [3] Iramina H,Nakamura M,Iizuka Y,et al. The accuracy of extracted target motion trajectories in four-dimensional cone-beam computed tomography for lung cancer patients[J]. Radiother Oncol,2016,121(1):46-51. DOI:10.1016/j.radonc.2016.07.022. [4] 王佳浩,李夏东,夏冰,等. NSCLC-SBRT中4D-CBCT图像配准方式研究[J]. 中华放射肿瘤学杂志,2016,25(1):71-75. DOI:10.3760/cma.j.issn.1004-4221.2016.01.018. Wang JH,Li XD,Xia B,et al. Study on image registration method of 4D-CBCT in NSCLC-SBRT[J]. Chin J Radiat Oncol,2016,25(1):71-75. DOI:10.3760/cma.j.issn.1004-4221.2016.01.018. [5] Li J,Harrison A,Yu Y,et al. Evaluation of Elekta 4D cone beam CT-based automatic image registration for radiation treatment of lung cancer[J]. Br J Radiol,2015,88(1053):20140620. DOI:10.1259/bjr.20140620. [6] Schreibmann E,Thorndyke B,Li T,et al. Four-dimensional image registration for image-guided radiotherapy[J]. Int J Radiat Oncol Biol Phys,2008,71(2):578-586. DOI:10.1016/j.ijrobp.2008.01.042. [7] Tan Z,Liu C,Zhou Y,et al. Preliminary comparison of the registration effect of 4D-CBCT and 3D-CBCT in image-guided radiotherapy of Stage ⅠA non-small-cell lung cancer[J]. J Radiat Res,2017,58(6):854-861. DOI:10.1093/jrr/rrx040. [8] Sweeney RA,Seubert B,Stark S,et al. Accuracy and inter-observer variability of 3D versus 4D cone-beam CT based image-guidance in SBRT for lung tumors[J]. Radiat Oncol,2012,7(1):81. DOI:10.1186/1748-717x-7-81. [9] Nakamura M,Ishihara Y,Matsuo Y,et al. Quantification of the kV X-ray imaging dose during real-time tumor tracking and from three-and four-dimensional cone-beam computed tomography in lung cancer patients using a Monte Carlo simulation[J]. J Radiat Res,2018,59(2):173-181. DOI:10.1093/jrr/rrx098. [10] Rit S1,Nijkamp J,van Herk M,et al. Comparative study of respiratory motion correction techniques in cone-beam computed tomography[J]. Radiother Oncol,2011,100(3):356-359. DOI:10.1016/j.radonc.2011.08.018. [11] Sonke JJ,Rossi M,Wolthaus J,et al. Frameless stereotactic body radiotherapy for lung cancer using four-dimensional cone beam CT guidance[J]. Int J Radiat Oncol Biol Phys,2009,74(2):567-574. DOI:10.1016/j.ijrobp.2008.08.004. [12] Sonke JJ,Lebesque J,van Herk M. Variability of four-dimensional computed tomography patient models[J]. Int J Radiat Oncol Biol Phys,2008,70(2):590-598. DOI:10.1016/j.ijrobp.2007.08.067. [13] Purdie TG,Moseley DJ,Bissonnette JP,et al. Respiration correlated cone-beam computed tomography and 4DCT for evaluating target motion in stereotactic lung radiation therapy[J]. Acta Oncol,2006,45(7):915-922. DOI:10.1080/02841860600907345. [14] Gottlieb KL,Hansen CR,Hansen O,et al. Investigation of respiration induced intra-and inter-fractional tumour motion using a standard Cone Beam CT[J]. Acta Oncol,2010,49(7):1192-1198. DOI:10.3109/0284186x.2010.498834. [15] Takahashi W,Yamashita H,Kida S,et al. Verification of planning target volume settings in volumetric modulated arc therapy for stereotactic body radiation therapy by using in-treatment 4-dimensional cone beam computed tomography[J]. Int J Radiat Oncol Biol Phys,2013,86(3):426-431. DOI:10.1016/j.ijrobp.2013.02.019. [16] Schaake EE,Rossi MM,Buikhuisen WA,et al. Differential motion between mediastinal lymph nodes and primary tumor in radically irradiated lung cancer patients[J]. Int J Radiat Oncol Biol Phys,2014,90(4):959-966. DOI:10.1016/j.ijrobp.2014.07.038. [17] Kida S,Masutani Y,Yamashita H,et al. In-treatment 4D cone-beam CT with image-based respiratory phase recognition[J]. Radiol Phys Technol,2012,5(2):138-147. DOI:10.1007/s12194-012-0146-5. [18] Kida S,Saotome N,Masutani Y,et al.4D-CBCT reconstruction using MV portal imaging during volumetric modulated arc therapy[J]. Radiother Oncol,2011,100(3):380-385. DOI:10.1016/j.radonc.2011.08.047. [19] Lagerwaard FJ,Van Sornsen de Koste JR,Nijssen-Visser MR,et al. Multiple “Slow” CT scans for in Corporating lung tumor mobility in radiotherapy planning[J]. Int J Radiat Oncol Biol Phys,2001,51(4):932-937. DOI:10.1016/S0360-3016(01)01716-3. [20] Gayou O,Colonias A. Imaging a moving lung tumor with megavoltage cone beam computed tomography[J]. Med Phys,2015,42(5):2347-2353. DOI:10.1118/1.4917524. [21] Vergalasova I,Maurer J,Yin FF. Potential underestimation of the internal target volume (ITV) from free-breathing CBCT[J]. Med Phys,2011,38(8):4689-4699. DOI:10.1118/1.3613153. [22] Harsolia A,Hugo GD,Kestin LL,et al. Dosimeteric advantages of four-dimensional adaptive image-guided radiotherapy for lung tumor using online cone-beam computed tomotherapy[J]. Int J Radiat Oncol Biol Phys,2008,70(2):582-589. DOI:10.1016/j.ijrobp.2007.08.078. [23] Schaake EE,Belderbos JS,Buikhuisen WA,et al. Mediastinal lymph node position variability in non-small cell lung cancer patients treated with radical irradiation[J]. Radiother Oncol,2012,105(2):150-154. DOI:10.1016/j.radonc.2012.09.007. [24] Yang Y,Schreibmann E,Li T,et al. Evaluation of on-board kV cone beam CT (CBCT)-based dose calculation[J]. Phys Med Biol,2007,52(3):685-705. DOI:10.1088/0031-9155/52/3/011. [25] van Zijtveld M,Dirkx M,Heijmen B. Correction of conebeam ct values using a planning ct for derivation of the dose of the day[J]. Radiother Oncol,2007,85(2):195-200. DOI:10.1016/j.radonc.2007.08.010. [26] Tucking T, McNitt-Gray M, Ruan D. Dose calculation on linac integrated kV-cone beam CT[J]. Radiother Oncol,2006,81(1):S26-S51. DOI:10.1118/1.4823795. [27] Hatton J,McCurdy B,Greer PB. Cone beam computerized tomography:the effect of calibration of the Hounsfield unit number to electron density on dose calculation accuracy for adaptive radiation therapy[J]. Phys Med Biol,2009,54(15):N329-346. DOI:10.1088/0031-9155/54/15/N01. [28] Cai W,Dhou S,Cifter F,et al.4D cone beam CT-based dose assessment for SBRT lung cancer treatment[J]. Phys Med Biol,2016,61(2):554-568. DOI:10.1088/0031-9155/61/2/554.