Abstract：Neoadjuvant chemoradiotherapy followed by TME is a common treatment at present for locally advanced rectal cancer. Several studies abroad in recent years have shown that statins have a positive effect on cancer resistance. We discussed the mechanism and clinical application of statins in preoperative neoadjuvant chemoradiotherapy of locally advanced rectal cancer.
Xie Shurui,Xu Benhua. Research progress of statins in neoadjuvant radiotherapy and chemotherapy for rectal cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(5): 394-397.
[1]Ferlay J,Soerjomataram I,Dikshit R,et al. Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN 2012[J].Int J Cancer,2015,136(5):E359-386. Doi:10.1002/ijc.29210. [2]Chen W,Zheng R,Baade PD,et al. Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.DOI:10.3322/caac.21338. [3]Boudrean DM,Yu O,Johnson J.Statin use and cancer risk:a comprehensive review[J].Exp Opin Dmg Saf,2010,9(4):603-621.DOI:10.1517/14740331003662620. [4]Nielsen SF,Nordestgaard BG,Bojesen SE.Statin use and reduced cancer-related mortality[J].N Engl J Med 2012;367:1792-1802.DOI:10.1056/NEJMoa1201735. [5]Trnberg SA,Holm LE,Carstensen JM,Eklund GA.Risks of cancer of the colon and rectum in relation to serum cholesterol and beta-lipoprotein. N Engl[J].Med,1986,315(26):1629-1633. [6]Poynter JN,Gruber SB,Higgins PD,et al. Statins and the risk of colorectal cancer. N Engl[J].Med,2005,352(21):2184-2192.DOI:10.1016/j.accreview.2005.08.195. [7]Siddiqui AA,Nazario H,Mahgoub A,et al. For patients with colorectal cancer,the long-term use of Statins is associated with better clinical outcomes[J].Dig Dis Sci,2009,54(6):1307-1311.DOI:10.1007/s10620-009-0790-8. [8]Qiu QC,Liu J,Shao JF,et al. Target-resequencing to identify micro RNA-associated SNP and predict the effect of SNP on microRNA function in colorectal cancer patients[J]. Chin J Oncol,2015,37(10):759-763.DOI:10.3760/cma.j.issn.0253-3766.2015.10.009. [9]Gray RT,Le ughrey MB,Bankhead P,et al. Tu1979-statin use,candidate mevalonate pathway biomarkers,and colon cancer survival inapopulation-based cohort study[J].Gastroenterology,2017,152(5):S1023-1024.DOI:10.1016/s0016-5085(17)33466-2. [0]Agabiti SS,Li J,Wiemer Aj. Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depltion,ERK phosphorylation and casppase activation[J].Cell Deat Dis,2017,8(3):e2678.DOI:10.1038/cddis.2017.101. [11]Loehhead P,Chan AT.Statins and colorectal cancer[J].Clin Gastroenterol Hepatol,2013,11(2):109-118.DOI:10.1016/j.cgh.2012.08.037. [12]Tauro M,McGuire J,Lynch CC.New approaches to selectively target cancer-associated matrix metalloproteniase activity[J].Cancer Metast Rev,2014,33(4):1043-1057.DOI:10.1007/s10555-014-9530-4. [13]Kang S,Kim ES,Moon A.Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras[J].Oncol Rep,2009,21(5):1317.DOI:10.3892/or_00000357. [4]Tsubaki M,Takeda T,Kino T,et al. Statins improve survival by inhibiting spontan eousmetastasis and tumorgrowth in a mouse melanoma model[J].Am J Cancer Res,2015,5(1O):3186.DOI:2156-6976/ajcr0015486. [15]Chang HL,Chen CY,Hsu YF,et al. Simvastatin induced HCT116 colorectalcancer cell apoptosis through p38MAPK-p53-survivin signaling cascade[J].Bioch Biophys Acta (BBA)-Gene Sub,2013,1830(8):4053-4064.DOI:10.1016/j.bbagen.2013.04.011. [16]Park HJ,Kong D,ArispeL I,et al.3-hydroxy-3-methylglutaryl coenzyme A reductase in hibitom interfere with angio-genesis by inhibiting the geranylgeranylation of RhoA[J].Circulat Res,2002,91(2):143-150.DOI:10.1161/01.res.0000028149.15986.4c. [17]Shiojima I,Walsh K.Role of Akt signaling in vascular homeostasis and angiogenesis[J].Circulat Res,2002,90(12):1243-1250.DOI:10116 1/01.res.0000022200.71892.9f. [18]Tsubaki M,Yamazoe Y,Yanae M,et al. Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF,HGF,and TGF-β as angiogenic factors in mouse osteosarcomaa[J].Cytokine,2011,54(1):100-107.DOI:10.1016/j.cyto.2011.01.005. [19]Karagkounis G,DeVecchio J,Ferrandon S,et al. Simvastatin enhances radiation sensitivity of colorectal cancer cells[J].Surg Endosc,2018 Mar;32(3):1533-1539.DOI:10.1007/s00464-017-5841-1. [20]Kodach LL,Jacobs RJ,Voorneveld PW,et al. Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell′stemness′ via the bone morphogenetic protein pathway[J].Gut,2011,60(11):1544-1553.DOI:10.1136/gut.2011.237495. [21]Videtic GM,Fisher BJ,Perera FE,et al. Preoperative radiation with concurrent 5-fluorouracil continuous infusion for locally advanced unresectable rectal cancer[J].Int J Radiat Oncol Biol Phys,1998,42(2):319-324.DOI:10.1016/S0360-3016(98)00214-4 [22]Wagman R,Minsky BD,Cohen AM,et al. Sphicter preservation with preoperative radiation therapy and coloanal anastomosis:Long term follow-up[J].Int J Radiat Oncol Biol Phys,1998,42(1):51-57. [23]Van de Velde CJH.Preoperative radiotherapy for rectal cancer. Br J Surg. 2001 Dec;88(12):1556-7.DOI:10.1046/j.0007-1323.2001.01986.x. [24]Mace AG,Gantt GA,Skacel M,et al. Statin therapy is associated with improved pathologic response to neoadjuvant chemoradiation in rectal cancer[J].Dis Colon Rectum,2013,56(11):1217-1227.DOI:10.1097/DCR.0b013e3182a4b236. [25]Katz MS,Minsky BD,Saltz LB,Association of statin use with a pathologic complete response to neoadjuvant chemoradiation for rectal cancer.[J].Int J Radiat Oncol Biol Phys,2005,62(5):1363-1370.DOI:10.1016/j.ijrobp.2004.12.033. [26]Armstrong D,Raissouni S,Price J,et al. Predictors of pathologic complete response after neoadjuvant treatment for rectal cancer:a multicenter study[J].Clin Colorectal Cancer,2015,14(4):291-295.DOI:10.1016/j.clcc.2015.06.001. [27]Hoffmeister M,Jansen L,et al. Statin use and survival after colorectal cancer:the importance of comprehensive confounder adjustment[J].J Natl Cancer Inst,2015,107(6):djv045.DOI:10.1093/jnci/djv045. [28]Hardie C,Jung Y,Jameson M.Effect of statin and aspirin use on toxicity and pathological complete response rate of neo-adjuvant chemoradiation for rectal cancer[J].Asia Pac J Clin Oncol,2016,12(2):167-173.DOI:10.1111/ajco.12468.
2019, Vol. 28 
