Research of obtaining pseudo-CT images based on ultrasound deformation fields in radiotherapy
Sun Hongfei1,2,4,Guo Chang3,Lin Tao2,4,Gao Liugang2,4,Sui Jianfeng2,4,Xie Kai2,4,Ni Xinye2,4,He Xia3,4
1Nanjing Medical University,Nanjing 211166,China; 2Department of Radiation Oncology,Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213003,China; 3Department of Radiation Oncology,Affiliated Cancer Hospital of Nanjing Medical University,Nanjing 210009,China; 4Center for Medical Physics Nanjing Medical University, Nanjing 211166, China
Abstract： Objective An improved method for obtaining pseudo-computed tomography (CTps) based on ultrasound deformation field. Methods The three-dimensional image data of computed tomography and ultrasound for three postoperative cervical cancer patients were selected,including the CT (CTsim) and ultrasound (USsim) images obtained during the simulated positioning stage,and the cone beam CT (CBCT) and ultrasound images obtained during the positioning verification stage of the treatment one week later. Binary masks of the OROI and OROW were created and applied in ultrasound image registration;thus,the deformation field was obtained. The deformation field was applied to CTsim images and different pseudo-CT images were obtained. Similarities between these pseudo-CT images and those of CBCT were compared,and registration accuracies between pseudo-CT images under different binary masks and CTsim were discussed. Results The averages of the correlation coefficient between pseudo-CT based on OROI,OROW,no binary mask and CBCT were 0.95,0.82 and 0.64 respectively. The average of the normalized mean square Error were 0.12,0.42 and 0.57 respectively. Conclusion The pseudo-CT based on OROI binary mask matches the best with CTsim and achieves the highest similarity with CBCT.
Sun Hongfei,Guo Chang,Lin Tao et al. Research of obtaining pseudo-CT images based on ultrasound deformation fields in radiotherapy[J]. Chinese Journal of Radiation Oncology, 2019, 28(4): 297-301.
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2019, Vol. 28 
