Analysis of clinical efficacy,failure pattern and prognostic factors of comprehensive treatment for malignant mucosal melanoma of head and neck
Sun Shiran, Yi Junlin, Gao Li, Huang Xiaodong, Luo Jingwei, Zhang Ye, Zhang Shiping, Wang Kai, Qu Yuan, Wu Runye, Liu Qingfeng, Chen Xuesong, Xiao Jianping, Xu Guozhen
Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China
Abstract：Objective To evaluate the clinical efficacy,failure pattern and prognostic factors of the malignant mucosal melanoma of the head and neck (MMHN) in a single center. Methods The treatment pattern,clinical efficacy,failure pattern and prognostic factors of 194 M0 MMHN patients admitted to our institution from 1982 to 2017 were retrospectively analyzed. Results The 5-year overall survival (OS),local recurrence-free survival (LRFS),regional recurrence-free survival (RRFS) and distant metastasis-free survival (DMFS) were 41.4%,57.8%,76.5% and 46.5%,respectively. The failure rate was calculated as 74.6%(141/189).Among them,40%(56/141) had distant metastasis as the first pattern of treatment failure,37%(52/141) had local relapse,15%(21/141) had regional relapse,5%(7/141) had concurrent distant metastasis and local/regional relapse and 3%(5/141) had concurrent local and regional relapse. Multivariate analysis demonstrated that surgical margins (P=0.001) and adjuvant radiotherapy (P=0.000) were the independent prognostic factors for LRFS. Conclusions Surgery combined with radiotherapy can yield relatively high LRFS in the comprehensive treatment of MMHN.Distant metastasis is the major failure pattern.
Sun Shiran,Yi Junlin,Gao Li et al. Analysis of clinical efficacy,failure pattern and prognostic factors of comprehensive treatment for malignant mucosal melanoma of head and neck[J]. Chinese Journal of Radiation Oncology, 2018, 27(12): 1041-1045.
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