Preliminary study of pencil beam scanning proton and carbon ion therapy for chordoma and chondrosarcoma of head and neck
Guan Xiyin, Gao Jing, Hu Jiyi, Hu Weixu, Yang Jing, Yang Youqi, Xu Tingting, Hu Chaosu, Lu Jiade, Kong Lin
Department of Radiation Oncology,Shanghai Proton and Heavy Ion Center,Shanghai 201315,China (Guan XY,Gao J,Hu JY,Hu WX,Yang J,Hu CS,Lu JD,Kong L);Department of Radiation Oncology,Cancer Hospital Affiliated to Fudan University,200032 Shanghai,China (Yang YQ,Xu TT,Hu CS,Kong L)
Objective To evaluate the short-term efficacy and adverse events of pencil beam scanning proton and carbon ion therapy in the treatment of chordoma and chondrosarcoma of the head and neck. Methods Between July 2014 and July 31,2017,61 patients with chordoma and chondrosarcoma of the head and neck receiving proton and heavy ion therapy as the first course of radiotherapy were enrolled. Among them,45 patients were diagnosed with chordoma and 16 cases of chondrosarcoma,39 male and 22 female. The median age was 38 years old (range:14-70 years).The median maximum tumor diameter was 4.1 cm (range:0-8.6 cm).The clivus and the cervical spine were the primary tumor sites. Results Eight patients received proton therapy,21 patients were treated with proton combined with carbon ion therapy and 32 patients received carbon ion therapy. All patients successfully completed the planned radiotherapy. The medial follow-up time was 21 months (range:7-47 months).No grade 3-4 acute toxicity was observed. Only one patient suffered from radiation-induced temporal lobe injury. The 2-year progression-free survival (PFS) and overall survival (OS) were 91% and 100%. Conclusions Pencil beam scanning proton and heavy ion therapy yields relatively favorable short-term outcomes in the treatment of chordoma and chondrosarcoma of the head and neck. Nevertheless,the long-term clinical efficacy and safety remain to be investigated during follow-up.
Guan Xiyin,Gao Jing,Hu Jiyi et al. Preliminary study of pencil beam scanning proton and carbon ion therapy for chordoma and chondrosarcoma of head and neck[J]. Chinese Journal of Radiation Oncology, 2018, 27(10): 886-889.
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2018, Vol. 27 
