Clinical features and prognosis analysis of 15 cases of extra-nodal nasal-type natural killer/T-cell lymphoma originated from the larynx
Tang Yu, Zhang Ximei, Wang Peiguo, Hou Xiaorong, Zhang Fuquan, Zhang Yujing, Zhu Yuan, Cao Jianzhong, Wu Junxin, Wu Tao, Zhu Suyu, Qian Liting, Qi Shunan, Yang Yong, Li Yexiong
Department of Radiation Oncology,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China (Tang Y,Qi SN,Yang Y,Li YX);
Department of Radiation Oncology,Tianjin Medical University Cancer Institute& Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Preventing and Therapy,Tianjin’ Clinical Research Center for Cancer,Tianjin 300060,China (Zhang XM,Wang PG);
Department of Radiation Oncology,Peking Union Medical College Hospital,Beijing 100730,China (Hou XR,Zhang FQ);
Department of Radiation Oncology,Sun Yat-sen University Cancer Center,Guangzhou 510060,China (Zhang YJ);
Department of Radiation Oncology,Zhejiang Cancer Hospital,Hangzhou 310022,China (Zhu Y);
Department of Radiation Oncology,Shanxi Cancer Hospital,Taiyuan 030013,China (Cao JZ);
Department of Radiation Oncology,Fujian Provincial Cancer Hospital Fuzhou 350013,China (Wu JX);
Department of Lymphoma,Guizhou Cancer Hospital,Guiyang 550000,China (Wu T);
Department of Radiation Oncology,Hunan Cancer Hospital,Changsha 410006,China (Zhu SY);
Department of Radiation Oncology,Anhui Cancer Hospital,Hefei 233004,China (Qian LT)
Objective To analyze the clinical features and prognosis of extra-nodal nasal NK/T cell lymphoma originated from the larynx. Methods Clinical data of 15 cases of extra-nodal nasal NK/T-cell lymphoma originated from the larynx were retrospectively analyzed. The overall survival (OS) and progression-free survival (PFS) were calculated by Kaplan-Meier survival analysis. The effect of different clinical factors on the clinical prognosis was assessed by univariate analysis. Results Among 15 patients,13 cases were male and 2 female. The median age of onset was 40 years. In 8 cases,the lesions were confined to the larynx,and only 4 cases suffered from cervical lymph node involvement. According to Ann Abor staging,11 cases were classified as grade I,3 as grade Ⅱ and 1 as grade Ⅲ.The median OS was 28.0 months and the 5-year OS was 32.0%.The median PFS was 24.7 months and the 5-year PFS was 33.3%.Among 14 patients with stage Ⅰ/Ⅱ,the clinical prognosis of patients receiving combined chemo-radiotherapy was significantly better than those of their counterparts undergoing radiotherapy or chemotherapy alone (median OS:37.2 vs.11.2 vs.3.7 months,P=0.004). Conclusion Extra-nodal nasal NK/T cell lymphoma originated from the larynx is extremely rare,predominantly in middle-aged male patients. The general condition is relatively favorable. Patients present with multiple lesions in the early stage and relatively poor prognosis. The clinical efficacy of chemotherapy combined with radiotherapy is probably higher compared with that of radiotherapy or chemotherapy alone.
Tang Yu,Zhang Ximei,Wang Peiguo et al. Clinical features and prognosis analysis of 15 cases of extra-nodal nasal-type natural killer/T-cell lymphoma originated from the larynx[J]. Chinese Journal of Radiation Oncology, 2018, 27(6): 593-597.
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