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中华放射肿瘤学杂志
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中华放射肿瘤学杂志  2018, Vol. 27 Issue (5): 455-462    DOI: 10.3760/cma.j.issn.1004-4221.2018.05.005
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阳性淋巴结区域预测食管鳞癌两野术后复发价值
王玉祥, 杨琼, 何明, 邱嵘, 李静, 齐战, 杨洁, 祝淑钗, 乔学英
050011 石家庄,河北医科大学第四医院放疗科(王玉祥、杨琼、邱嵘、李静、杨洁、祝淑钗、乔学英),胸外科(何明、齐战)
Value of positive lymph node metastasis region in predicting postoperative recurrence for patients with esophageal squamous cell carcinoma after two-field esophagectomy
Wang Yuxiang, Yang Qiong, He Ming, Oiu Rong, Qi Zhan, Yang Jie, Zhu Shuchai, Qiao Xueying
Department of Radiation Oncology (Wang YX,Yang Q,Oiu R,Li J,Yang J,Zhu SC,Qiao XY),Department of Thoracic Surgery (He M,Qi Z),Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China
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摘要 目的 食管鳞癌两野术后有阳性淋巴结转移者复发率很高,回顾分析食管鳞癌术后淋巴结转移者,采用术后淋巴结转移区域预测术后复发的价值。方法 收集329例胸段食管鳞癌两野R0术后淋巴结转移患者资料,术后淋巴结转移区域位于上腹部、纵隔、纵隔+上腹部者分别为116、119、94例。计数资料行χ2检验,Logistic多因素回归分析评价影响术后复发因素;累积复发率采用Kaplan-Meier法计算和Logrank法检验,Cox模型多因素分析。结果 总复发率为72.4%(239/329),总局部区域复发率为58.1%(139/329),其中颈部、纵隔和上腹部复发率分别为14.6%、42.9%和10.0%。多因素回归分析显示术后淋巴结转移区域是影响术后总复发和局部区域复发的因素(P<0.05)。术后淋巴结转移区域位于上腹部、纵隔、纵隔+上腹部者术后总复发率和局部区域复发率分别为57.8%、77.3%、85.1%和44.0%、62.3%、72.3%;术后淋巴结转移区域也是影响术后纵隔和上腹部复发的因素(P<0.05),但不影响颈部复发(P>0.05);术后淋巴结转移区域位于上腹部、纵隔、纵隔和上腹部者,术后纵隔和上腹部复发率分别为27.6%、47.1%、56.4%和12.9%、4.2%、13.8%。结论 食管鳞癌两野术后淋巴结转移者失败原因主要为局部区域复发;术后淋巴结转移区域可以预测术后总复发和局部区域复发,尤其是术后纵隔或上腹部复发,其结果有助于指导术后辅助放疗靶区设计。
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关键词 食管肿瘤/鳞癌食管切除术/两野淋巴结转移复发    
AbstractObjective The recurrence rate is alarmingly high in patients with positive lymph node metastasis (pN+) esophageal squamous cell carcinoma (ESCC) after two-field surgery. This study aims to retrospectively evaluate the value of pN+ region in predicting postoperative recurrence in patients with pN+ thoracic ESCC after two-field radical esophagectomy. Methods A total of 329 patients with pN+ thoracic ESCC after two-field R0 esophagectomy were enrolled in this study. After surgery,pN+ region was located at the upper abdomen in 116 patients,mediastinum in 119 and upper abdomen plus mediastinum in 94, respectively. The enumeration data were analyzed by chi-square test. Logistic multivariate regression analysis was performed to evaluate the risk factors of postoperative recurrence. Cumulative recurrence rate was statistically analyzed by using Kaplan-Meier method, Log-rank test and Cox model multivariate analysis. Results The overall recurrence rate was 72.4%(239/329).The overall locoregional recurrence (LR) rate was 58.1%(139/329) including 14.6% in the neck,42.9% in the mediastinum and 10.0% in the upper abdomen. Multivariate logistic and Cox regression analyses demonstrated that pN+ region was the only independent factor affecting the overall recurrence and LR rates (both P<0.05).The overall recurrence and LR rates were 57.8% and 44.0% for patients with pN+ region in the upper abdomen,77.3% and 62.3% for those with pN+ region in the mediastinum and 85.1% and 72.3% for their counterparts with pN+ region in the upper abdomen and mediastinum,respectively. Additionally pN+ region was also the independent factor of the recurrence in the mediastinum or upper abdomen (both P<0.05) rather than the neck (P>0.05).The recurrence rates in the mediastimun and upper abomen were 27.6% and 12.9% for patients with pN+ region in upper abdomen,47.1% and 4.2% for those with pN+ region in the mediastinum,and 56.4% and 13.8% for patients with pN+ region in the upper-abdomen plus mediastinum,respectively. Conclusions LR is the main cause of failure in patients with pN+ thoracic ESCC after two-field R0 surgery.pN+ region can be utilized to predict the overall recurrence and LR rates,especially for patients with postoperative recurrence in the the mediastinum and upper abdomen. The findings in this investigation contribute to the design of the target volume of postoperative adjuvant radiotherapy.
Key wordsEsophageal neoplasm/esophageal squamous cell carcinoma    Esophagectomy/two-field    Lymph node metastasis    Recurrence   
收稿日期: 2017-07-24     
引用本文:   
. 阳性淋巴结区域预测食管鳞癌两野术后复发价值[J]. 中华放射肿瘤学杂志, 2018, 27(5): 455-462.
. Value of positive lymph node metastasis region in predicting postoperative recurrence for patients with esophageal squamous cell carcinoma after two-field esophagectomy[J]. Chinese Journal of Radiation Oncology, 2018, 27(5): 455-462.
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