伽马刀FSRT颅内囊变型转移瘤的临床分析

doi:10.3760/cma.j.issn.1004-4221.2018.02.002

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摘要目的分析伽马刀FSRT在颅内囊变性转移瘤治疗中的作用。方法对2013—2015年间治疗的 189例颅脑转移瘤373个病灶筛选出 40例伴有61个囊变性转移灶者。所有病灶均采用伽马刀FSRT,50%等剂量线定义为处方剂量线,处方剂量 40~48 Gy分 10~12次。Kaplan-Meier法计算生存率,Logrank法检验单因素分析。结果中位随访21个月(6~39个月),中位生存期15.3个月,6个月、1、2年LC率分别为93%、82%,79%,1、2年生存率分别为63%、30%。单因素分析显示囊变体积、病灶体积与LC率均无关(P=0.17、0.48)。结论采用伽玛刀治疗脑囊变性转移瘤具有与实体转移瘤相似的有效率,LC率与安全性值得临床借鉴与应用。

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	贺选
	赵晨年
	杜建飞
	高红祥
	张军维
	王洋
	张学成

关键词 ：肿瘤, 囊变性脑转移/放射疗法, 放射疗法, 伽马射线立体定向, 治疗结果

Abstract：Objective To analyze the clinical efficacy of gamma-ray fractionated stereotactic radiotherapy (FSRT) in the treatment of intracranial metastatic polycystic tumors. Methods Forty cases with 61 metastatic polycystic tumors were selected from 189 patients with 373 intracranial metastatic tumors admitted to our hospital from 2013 to 2015. All cases received gamma-ray FSRT. The isodose line at 50% was defined as the prescription dose. The prescription dose was ranged from 40 to 48 Gy/10-12f. The survival rate was calculated by Kaplan-Meier method. The single factor analysis was performed by Log-rank method. Results The median follow-up time was 21months (range:6-39 months).The median survival time was 15.3 months. The 6-month, 1-and 2-year local control rate was 93%, 82% and 79%, respectively. The 1-and 2-year survival rate was 63% and 30%. Single factor analysis demonstrated that the volume of cysts and the volume of lesions were not significantly correlated with local control rate (P=0.17 and 0.48). Conclusion Gamma-ray FSRT can be adopted to treat intracranial metastatic polycystic tumors, which yields similar clinical efficacy to metastatic solid tumors. It deserves wide application in clinical practice due to high local control rate and safety.

Key words： Neoplasm,cystic brain metastasis/radiotherapy Radiotherapy,gamma-ray stereotactic Treatment outcome

收稿日期: 2017-07-12

通讯作者: 张学成,Email:13571987537@139.com

引用本文:

贺选,赵晨年,杜建飞等. 伽马刀FSRT颅内囊变型转移瘤的临床分析[J]. 中华放射肿瘤学杂志, 2018, 27(2): 132-134.

He Xuan,Zhao Chennian,Du Jianfei et al. Clinical analysis of gamma-ray fractionated stereotactic radiotherapy for intracranial metastatic polycystic tumors[J]. Chinese Journal of Radiation Oncology, 2018, 27(2): 132-134.

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