两套TPS之间VMAT计划优化质量评价研究

doi:10.3760/cma.j.issn.1004-4221.2017.10.018

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摘要

目的探讨两套商用TPS实施VMAT优化的性能特点。方法随机选取本院宫颈癌和前列腺癌患者各10例,分别利用瓦里安Eclipse和飞利浦Pinnacle TPS设计VMAT计划(宫颈癌2Arc、3Arc,前列腺癌1Arc、2Arc),采用瓦里安Clinac iX加速器配备RapidArc技术实施照射。从剂量分布、实施效率、治疗照射参数等方面评价治疗计划质量的差异。对组间比较行配对t检验。

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	杨涛
	徐伟
	徐寿平
	曲宝林
	葛瑞刚
	戴相昆
	解传滨
	丛小虎
	龚璇

关键词 ：宫颈癌/放射治疗, 前列腺癌/放射治疗, 容积调强弧形疗法, 计划质量基金项目:国家重点研发课题(2017YFC0112105), 青年科学基金项目(61601012)

Abstract：

Objective To investigate the plan quality between two treatment planning systems (TPSs) for volumetric modulated arc therapy (VMAT). Methods VMAT plans based on Varian Eclipse and Philips Pinnacle TPS were designed for 10 cervical cancer patients (2, 3 Arcs) and 10 prostate cancer patients (1, 2 Arcs). The delivery system of VMAT was Varian ClinaciX machine, and RapidArc was used. The treatment plan quality between the two TPSs was evaluated based on dose distribution, delivery efficiency, and parameter settings. The differences between the two TPSs were compared using paired t-test. Results For cervical cancer patients, the 2-Arc VMAT plans based on the Pinnacle was slightly better than those based on the Eclipse in terms of the conformal index (CI) of planning target volume (PTV), rectum V₃₀ and V₄₀, and bladder V₃₀ and V₄₀, and the homogeneity index (HI) of PTV and PTV₁ as well as CI of PTV₁ in theEclips were slightly better than those in the Pinnacle(P<0.05)Pinnacle were slightly worse than those in the Eclipse (P>0.05). The number of monitor units with 2-Arcs and 3-Arcs plans of the Eclipse was significantly smaller than those in the Pinnacle (P<0.05). For prostate cancer patients, The 1-arc VMAT plans of the Pinnacle TPS were slightly superior to those of the Eclipse TPS in terms of the HI of PTV, rectumV₃₀ and V₄₀, and bladderV₃₀ and V₄₀, but the former was slight inferior to the latter in terms of the CI of PTV (P<0.05). The number of monitor units of 1-arc and 2-Arcs plans showed no significant difference between the two TPSs (P>0.05). Conclusions For patients with cervical cancer and prostate cancer, the VMAT plans based on Varian Eclipse and Philips Pinnacle TPS can achieve a clinically acceptable dose distribution and show a little difference in the treatment plan quality. However, we will still need more cases to further study and determine the performance characteristics of the commercial TPSs for optimizing VMAT.

Key words： Cervical cancer/radiotherapy Prostate cancer/radiotherapy Volumetric modulated arc treatment Plan quality

收稿日期: 2016-07-18

通讯作者: 徐寿平,Email:shouping_xu@yahoo.com

引用本文:

杨涛,徐伟,徐寿平等. 两套TPS之间VMAT计划优化质量评价研究[J]. 中华放射肿瘤学杂志, 2017, 26(10): 1192-1198.

Yang Tao,Xu Wei,Xu Shouping et al. Evaluation of plan quality between two treatment planning systems for volumetric modulated arc therapy[J]. Chinese Journal of Radiation Oncology, 2017, 26(10): 1192-1198.

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http://journal12.magtechjournal.com/Jweb_fszlx/CN/10.3760/cma.j.issn.1004-4221.2017.10.018 或 http://journal12.magtechjournal.com/Jweb_fszlx/CN/Y2017/V26/I10/1192

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