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妇科恶性肿瘤治疗后下肢淋巴水肿危险因素Meta分析
常新,沈娇凤,彭啟亮,庄志祥,田野
215004 苏州大学附属第二医院肿瘤科(常新、沈娇凤、庄志祥),放疗科(彭啟亮、田野)
Risk factors for lower extremity lymphedema following treatment of gynecologic cancers:a meta-analysis
Chang Xin,Shen Jiaofeng,Peng Qiliang,Zhuang Zhixiang,Tian Ye
Department of Oncology (Chang X,Shen JF,Zhuang ZX),Department of Radiotherapy& Oncology (Peng QL,Tian Y),Second Affiliated Hospital of Soochow University,Suzhou 215004,China
Abstract：Objective To investigate the multiple risk factors for lower extremity lymphedema in patients following treatment of common gynecologic cancers by meta-analysis for systematic analysis and comprehensive quantitative study. Methods Clinical trials published up until August 2016 were retrieved from PubMed, Embase, and the Cochrane Library. The quality of the included studies was assessed by the Newcastle-Ottawa Scale, and data analysis was performed using Stata 14.0 and RevMan 5.3. The strength of the associations between risk factors and gynecologic cancer-related lower extremity lymphedema was described as odds ratio (OR) and 95% confidence intervals (CI). Results Eighteen studies were included in the meta-analysis, and 8 relevant factors were identified. The risk factors for lower extremity lymphedema after treatment of gynecologic cancer mainly included radiotherapy (OR=2.45, 95%CI:2.05-2.95, P=0.000), FIGO stage (OR=2.29, 95%CI:1.66-3.14, P=0.000), and pelvic lymph node dissection (OR=2.00, 95%CI:1.02-3.91, P=0.040). Conclusions Radiotherapy, FIGO stage, and pelvic lymph node dissection are the main risk factors for lower extremity lymphedema after treatment of gynecologic cancers.
Chang Xin,Shen Jiaofeng,Peng Qiliang et al. Risk factors for lower extremity lymphedema following treatment of gynecologic cancers:a meta-analysis [J]. Chinese Journal of Radiation Oncology, 2017, 26(9): 1038-1044.
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2017, Vol. 26 
