外周T细胞淋巴瘤临床治疗进展

doi:10.3760/cma.j.issn.1004-4221.2017.05.024

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摘要

外周T细胞淋巴瘤是一组起源于胸腺后成熟T细胞的侵袭性非霍奇金淋巴瘤,具有高度的异质性,目前临床研究进展滞后于B细胞淋巴瘤。现有治疗方案治愈率低,总体预后差,目前仍缺乏标准治疗方案。采用常规的CHOP类化疗疗效欠佳,放疗在早期患者中的价值尚有待确定,造血干细胞移植是高危患者巩固治疗的首选,新型药物在外周T细胞淋巴瘤疗效仍需进一步证实。PET/CT在外周T细胞淋巴瘤患者中的预后判断中发挥着越来越重要的作用。

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	吴峥
	朱苏雨

关键词 ： T细胞淋巴瘤, 治疗, 预后

Abstract：

Peripheral T-cell lymphoma (PTCL) is a highly specific and invasive non-Hodgkin’s lymphoma derived from mature T-cells that leave the thymus. At present, the clinical progress in PTCLs is behind that in B-cell lymphomas, and the current treatments for PTCLs have low efficacy and poor overall prognosis. Therefore, there is currently still no standard treatment for PTCL. The efficacy of the conventional CHOP chemotherapy regimen is poor, and the value of radiotherapy in early-stage PTLC patients remains to be determined. Autologous hematopoietic stem cell transplantation is the top choice for consolidation treatment for high-risk patients, but the efficacy of novel drugs for PTCLs needs to be further confirmed. In addition, PET/CT plays a more important role in predicting the prognosis of PTCLs.

Key words： T-cell lymphomas Treatment Prognosis

收稿日期: 2017-01-03

通讯作者: 朱苏雨,Email:zhusuyu@hnszlyy.com

引用本文:

吴峥,朱苏雨. 外周T细胞淋巴瘤临床治疗进展[J]. 中华放射肿瘤学杂志, 2017, 26(5): 588-592.

Wu Zheng,Zhu Suyu. Advances in therapeutic options for peripheral T-cell lymphomas[J]. Chinese Journal of Radiation Oncology, 2017, 26(5): 588-592.

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http://journal12.magtechjournal.com/Jweb_fszlx/CN/10.3760/cma.j.issn.1004-4221.2017.05.024 或 http://journal12.magtechjournal.com/Jweb_fszlx/CN/Y2017/V26/I5/588

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