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| miR-124过表达增强人宫颈癌细胞放射敏感性 |
| 刘艳杰 ,顾浩 ,史惠蓉 ,乔玉环 ,韩丽萍, 边爱平, 张梦真, 纪妹 ,郭红军, 常青 ,郭瑞霞 |
| 450052 郑州大学第一附属医院妇科(刘艳杰、史惠蓉、乔玉环、韩丽萍、边爱平、张梦真、纪妹、郭红军、常青、郭瑞霞),放疗科(顾浩 |
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摘要 中晚期患者首选根治性放疗,部分患者还需术前或术后放疗,然后导致疗后复发的主要原因是放射抵抗[1],因此提高放射敏感性是目前宫颈癌放疗研究重点。miRNA是一类小的长度约20~22个核苷酸的非编码单链RNA,在生物转化中具有重要的调控作用[2]。miRNA作用广泛,不仅参与细胞分化增殖和细胞凋亡,有防御病毒的功能,还可能影响肿瘤的发生和发展[3]。发现miR-124在多形性胶质瘤[4]、口腔鳞状细胞癌[5]、乳腺癌、宫颈癌[6]等中表达下降,扮演着癌基因的角色。目前研究表明miR-124过表达可以抑制宫颈癌细胞增殖、侵袭和转移[7-8],但miR-124过表达对宫颈癌细胞对放射敏感性的影响尚罕见文献报道。本研究以宫颈癌HeLa细胞为对象,研究miR-124过表达能否增强宫颈癌细胞的放射敏感性及其作用机制,为以miR-124为靶点联合放疗的宫颈癌治疗方案提供科学依据。
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收稿日期: 2016-10-11
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2017, Vol. 26 
