Research advances in stereotactic body radiation therapy for primary liver cancer
Tong Jinlong,Zheng Qin,Sun Xinchen
Department of Radiation Oncology,Affliated Second Hospital of Southeast University,Nanjing 210029,China (Tong JL,Zheng Q);Department of Radiation Oncology,First Hospital of Nanjing Medical University,Nanjing 210029,China (Sun XC)
Abstract：Stereotactic body radiation therapy (SBRT) adopts different tumor-killing mechanisms from the conventional fractionated radiotherapy. In SBRT, a single high-dose radiation can destroy the membrane of tumor cells and induce the release of tumor-associated antigen, also named in situ tumor vaccine, which stimulates the immune system to kill the residual tumor;a single-fraction radiation with a dose larger than 8-10 Gy can induce rapid apoptosis of vascular endothelial cells via the acid sphingomyelinase pathway at 1-6 hours after radiation, which causes tumor vascular occlusion and secondary tumor-killing effects. In order to understand whether SBRT improves the clinical treatment outcomes via the above mechanisms, this paper reviews the clinical research advances in SBRT for primary liver cancer.
Tong Jinlong,Zheng Qin,Sun Xinchen. Research advances in stereotactic body radiation therapy for primary liver cancer[J]. Chinese Journal of Radiation Oncology, 2017, 26(2): 234-238.
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