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中华放射肿瘤学杂志
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中华放射肿瘤学杂志  2016, Vol. 25 Issue (9): 929-933    DOI: 10.3760/cma.j.issn.1004-4221.2016.09.004
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食管癌术后辅助放化疗不良反应临床分析
沈文斌,高红梅,曹彦坤,祝淑钗,李幼梅,李曙光,李娟,刘志坤,苏景伟
050011 石家庄,河北医科大学第四医院放疗科(沈文斌、曹彦坤、祝淑钗、李幼梅、李曙光、李娟、刘志坤、苏景伟);050011石家庄市第一医院放射科(高红梅)
A clinical analysis of adverse reactions of postoperative adjuvant radiochemotherapy for esophageal carcinoma
Shen Wenbin,Gao Hongmei,Cao Yankun,Zhu Shuchai,Li Youmei,Li Shuguang,Li Juan,Liu Zhikun,Su Jingwei
Department of Radiation Oncology,Forth Hospital,Hebei Medical University,Shijiazhaung 050011,China (Shen WB,Cao YK,Zhu SHCH,Li YM,Li SHG,Li J,Liu ZHK,Su JW);Department of Radiation,The First Hospital of Shijiazhaung,Shijiazhaung 050011,China (Gao HM)
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摘要 目的 观察食管癌术后辅助性放化疗患者不良反应发生情况及其与临床因素的关系。方法 对2014年49例接受了术后辅助性放化疗的食管癌患者出现RG、RP及骨髓抑制情况进行Logistic法因素分析。结果 全组患者出现2级RG 19例(39%),2级RP 7例(14%),2级骨髓抑制8例(16%)。单因素分析结果显示与2级RG发生相关因素为胃长度大小(P=0.016);与2级RP发生相关因素为性别(P=0.026)和胃体积大小(P=0.047);与2级骨髓抑制发生相关因素为是否接受了≥2个周期化疗(P=0.000)。多因素分析结果显示胃长度大小为2级RG独立影响因素(P=0.038);胃体积大小为2级RP独立影响因素(P=0.013)。结论 术后胸腔胃状态影响着食管癌术后患者不良反应的发生情况,胃长度越长可能会增加2级RG的发生率,胃体积越大可能会增加2级RP的发生率。
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沈文斌
高红梅
曹彦坤
祝淑钗
李幼梅
李曙光
李娟
刘志坤
苏景伟
关键词 食管肿瘤/术后放射疗法食管肿瘤/术后化学疗法不良反应因素分析    
AbstractObjective To investigate the incidence of adverse reactions in patients treated with postoperative adjuvant radiochemotherapy for esophageal carcinoma and its relationship with clinical factors. Methods Logistic regression was used for variate analyses on the incidence of radiation gastritis (RG), radiation pneumonia (RP), and marrow suppression in 49 patients with esophageal cancer who received postoperative adjuvant radiochemotherapy in 2014. Results In all the patients, 19(39%) patients had grade 2 RG, 7(14%) patients grade 2 RP, and 8(16%) patients grade 2 marrow suppression. The univariate analysis showed that the length of stomach was associated with the incidence of grade 2 RG (P=0.016);sex and the volume of stomach were associated with the incidence of grade 2 RP (P=0.026;P=0.047);≥2 cycles of chemotherapy were associated with the incidence of grade 2 marrow suppression (P=0.000). The multivariate analysis showed that the length of stomach was an independent factor for grade 2 RG (P=0.038) and the volume of stomach was an independent factor for grade 2 RP (P=0.013). Conclusions The postoperative state of the intrathoracic stomach affects the incidence of adverse reactions in patients with esophageal carcinoma. A longer stomach may cause higher incidence of grade 2 RG and a larger stomach may cause higher incidence of grade 2 RP.
Key wordsEsophageal neoplasms/postoperative radiotherapy    Esophageal neoplasms/postoperative chemotherapy    Side effects    Factor analysis   
收稿日期: 2015-09-21     
通讯作者: 祝淑钗,Email:sczhu1965@163.com   
引用本文:   
沈文斌,高红梅,曹彦坤等. 食管癌术后辅助放化疗不良反应临床分析[J]. 中华放射肿瘤学杂志, 2016, 25(9): 929-933.
Shen Wenbin,Gao Hongmei,Cao Yankun et al. A clinical analysis of adverse reactions of postoperative adjuvant radiochemotherapy for esophageal carcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(9): 929-933.
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