Department of Radiation Oncology,Forth Hospital,Hebei Medical University,Shijiazhaung 050011,China (Shen WB,Cao YK,Zhu SHCH,Li YM,Li SHG,Li J,Liu ZHK,Su JW);Department of Radiation,The First Hospital of Shijiazhaung,Shijiazhaung 050011,China (Gao HM)
Abstract：Objective To investigate the incidence of adverse reactions in patients treated with postoperative adjuvant radiochemotherapy for esophageal carcinoma and its relationship with clinical factors. Methods Logistic regression was used for variate analyses on the incidence of radiation gastritis (RG), radiation pneumonia (RP), and marrow suppression in 49 patients with esophageal cancer who received postoperative adjuvant radiochemotherapy in 2014. Results In all the patients, 19(39%) patients had grade 2 RG, 7(14%) patients grade 2 RP, and 8(16%) patients grade 2 marrow suppression. The univariate analysis showed that the length of stomach was associated with the incidence of grade 2 RG (P=0.016);sex and the volume of stomach were associated with the incidence of grade 2 RP (P=0.026;P=0.047);≥2 cycles of chemotherapy were associated with the incidence of grade 2 marrow suppression (P=0.000). The multivariate analysis showed that the length of stomach was an independent factor for grade 2 RG (P=0.038) and the volume of stomach was an independent factor for grade 2 RP (P=0.013). Conclusions The postoperative state of the intrathoracic stomach affects the incidence of adverse reactions in patients with esophageal carcinoma. A longer stomach may cause higher incidence of grade 2 RG and a larger stomach may cause higher incidence of grade 2 RP.
Shen Wenbin,Gao Hongmei,Cao Yankun et al. A clinical analysis of adverse reactions of postoperative adjuvant radiochemotherapy for esophageal carcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(9): 929-933.
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