Abstract：Objective To evaluate the effects of respiratory on dose distributions in three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT). MethodsThe dose distributions were measured with a Sun Nuclear Mapcheck 2D-ARRAY placed on a moving platform home-made to simulate the respiratory. The periodic motion of the moving platform was 3.5 s. The rang of the moving platform was ±3 mm,±5 mm,±10 mm,±15 mm. Dosimetric comparisions for 3DCRT and IMRT plans were performed by means of Gamma analysis with 3% and 3 mm, respectively. Dates of two groups were used by paired t-test. Results The respiratory could reduce the target dose and conformal index, blurring effect of dose distribution. The pass rate (3%/3 mm) in 3DCRT was greater than it in IMRT of the 11 cases, and P<0.05;The failed points were mainly near the field edge for 3DCRT plans, but located in the whole target volumes for IMRT plans. Conclusions Respiratory motion blurred the dose distribution of 3DCRT and IMRT, yet the influence on IMRT was much more striking. As for tumors with large motion amplitude, it is advisable to use 3DCRT rather than IMRT techniques. 3DCRT may deliver a more reliable dose distribution by cautiously delineating the PTV margin.
Ruan Changli,Song Qibin,Xu Liming et al. Simulafion of respiratory motion effect on dose distributions in three-dimensional radiotherapy of tumor[J]. Chinese Journal of Radiation Oncology, 2014, 23(5): 418-421.
[1] Shi HS, Gao X, Li D, et al. A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation[J]. Int J Nanomed,2012,7:2601-2611. [2] Happerset L, Mageras GS, Zdefsky MJ, et al. A study of internal organ motion on dose escalation in conformal prostatetreatments[J].Radiother Oneol,2003,66:263-270. [3] ICRU.ICRU No.62.Prescribing, recording, and reporting photon beam therapy (Supplement to ICRU Report 50)[R].Bethesda:ICRU,1999. [4] Mutic S, Palta JR, Botker EK, et al. Report of the AAPM radiation therapy committee task group No.66[J]. Med Phys,2003,30:2762-2792. [5] Baiter JM, Ten RK, Lawrence TS, et al.Uncertainties in CT based radiation therapy treatment planning associated with patient breathing[J].Int J Radiat Oncol Biol Phys,1996,36:167-174. [6] 曹永珍,黑月林,吕仲虹,等.立体定向放射治疗中肿瘤和膈肌动度的研究[J].中华放射肿瘤学杂志,2000,9:262-265. [7] 于甬华,赵月环,罗立民,等.呼吸运动对肝部占位性病灶化置的影响及数学模型的建立[J].中华放射肿瘤学杂志,2002,11:245-247. [8] 于甬华,吴玉芬,郭守芳,等.呼吸运动对周围型肺癌位置的影响及其数学模型的建立[J].中华放射肿瘤学杂志,2004,13:83-84.
2014, Vol. 23 
