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鼻腔恶性肿瘤伴乳腺转移的临床表现及预后
曲媛,易俊林,黄晓东,王凯,高黎
100021 北京协和医学院 中国医学科学院肿瘤医院放疗科
The characteristics and prognosis of meteastases to the breast from nasal cavity tumors
Qu Yuan, Yi Junlin, Huang Xiaodong, Wang Kai, Gao Li
Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021,China Corresponding author;Gao Li, Email:gaowh@cicams.ac.cn
Abstract：Objective To detect the clinical features and prognostic factors of nasal cavity malignancy with breast metastasis. Methods 846 Patients with nasal cavity malignancy from January 1999 to December 2011 were enrolled, the clinical and pathological features, clinical diagnostic methods and prognostic factors for breast metastasis patients were analyzed. Results Six female cases (median age 25) were diagnosed with breast metastasis, including 3 rhabdomyosarcoma and 3 olfactory neuroblastoma;consisting 0.7% of the total 846 cases of primary nasal malignancy group. The metastasis were more likely to be multiple breast lesions with/without metastasis in other site. For the primary tumor, five patients received 66-72 Gy/30-33f of radical radiotherapy, one patient with rest rhabdomyosarcoma received 58 Gy of palliative radiation since breast metastasis was found after 14 Gy of radiation and breast mass resection were performed right after. For the breast metastasis, five of 6 patients received breast surgery, one patients with olfactory neuroblastoma received 6 cycles cyclophosphamide+adriamycin+vincristine chemotherapy. Median survival was 12.7 months. Conclusions For nasal cavity malignancy, breast metastasis more likely occur in younger female patients. Ultrasound may provide useful information in evaluating breast metastasis. Cases combined with metastasis except breast have unfavorable prognosis.
Qu Yuan,Yi Junlin,Huang Xiaodong et al. The characteristics and prognosis of meteastases to the breast from nasal cavity tumors[J]. Chinese Journal of Radiation Oncology, 2014, 23(5): 411-414.
[1] Bolla M, Vroussos C, Roux O, et al. Esthesioneuroblastoma:general review about three new cases (author′s transl)[J].Bull Cancer,1980,67:325-332. [2] Shetty SC, Gupta S, Chary G, et al. Olfactory neuroblastoma metastatic to the breast[J].Rhinology,2000,38:144-146. [3] Wurm J, Constantinidis J, Grabenbauer GG, et al. Otolaryngol Rhabdomyosarcomas of the nose and paranasal sinuses:treatment results in 15 cases[J]. Head Neck Surg,2005,133:42-50. [4] Alva S, Shetty-Alva N. An update of tumor metastasis to the breast data[J]. Arch Surg,1999,134:450. [5] Mihai R, Christie-Brown J, Bristol J. Breast metastases from colorectal carcinoma[J]. Breast,2004,13:155-158. [6] Toombs BD, Kalisher L. Metastatic disease to the breast:clinical, pathologic, and radiographic features[J].Am J Roentgnol,1977,129:673-676. [7] Vizcaíno I, Torregrosa A, Higueras V, et al. Metastasis to the breast from extramammary malignancies:a report of four cases and a review of literature[J]. Eur Radiol,2001,11:1659-1665. [8] Sheen-Chen SM, Eng HL, Ko SF. Metastatic rhabdomyosarcoma to the breast[J].Anticancer Res,2005,25:527-529. [9] Merced C, Rubio IT, Rodríguez J, et al. Breast metastasis from rhabdomyosarcoma of the nasal septum in a pregnant adult woman[J].Breast J,2011,17:420-421. [10] McIntosh IH, Hooper AA, Millis RR, et al. Metastatic carcinomawithin the breast[J]. Clin Oncol,1976,2:393-401. [11] Akcay MN. Metastatic disease in the breast[J]. Breast,2002,11:526-528. [12] Smymiotis V, Theodosopoulos T, Marinis A, et al. Metastaticdisease in the breast from nonmammary neoplasms[J]. Eur J Gynaecol Oncol,2005,26:547-550. [13] Georgiannos SN, Chin J, Goode AW, et al. Secondary neoplasmsof the breast:a survey of the 20th Century[J]. Cancer,2001,92:2259-2266.
2014, Vol. 23 
