Abstract：Objective To analyze the therapeutic effects of different treatment modalities in patients with tongue squamous cell carcinoma. Methods A retrospective analysis was performed on the complete clinical and follow-up data of 132 patients with pathologically confirmed tongue squamous cell carcinoma, who were initially treated at the First Affiliated Hospital of Xinjiang Medical University from 2003 to 2011. The Kaplan-Meier method was used to calculate the overall survival (OS) rates for patients who received surgery alone (S), radiotherapy alone (R), surgery plus radiotherapy (S+R), chemotherapy plus surgery (C+S), chemotherapy plus radiotherapy (C+R), and surgery, radiotherapy, and chemotherapy (S+R+C). The OS was compared between these groups by log-rank test. Multivariate analysis was performed using the Cox proportional hazard model to establish independent treatment modalities as prognostic factors. Results The follow-up rate was 100%. The 3-year sample size was 94. The 3-year OS rate for all patients was 72.7%. The univariate analysis showed that among 70 stage Ⅰ and Ⅱ patients, the S, R, S+R, C+S, and S+R+C groups had 3-year OS rates of 86%, 67%, 97%, 100%, and 82%, respectively (P=0.018);among 62 stage Ⅲ and IV patients, the S, R, S+R, C+S, C+R, and S+R+C groups had 3-year OS rates of 38%, 14%, 92%, 40%, 14%, and 67%, respectively (P=0.000). The multivariate analysis showed that S+R and S+R+C were independent prognostic factors (P=0.000 and 0.005). Conclusions Surgery alone or combination therapy including surgery has a good therapeutic effect for stage Ⅰ—Ⅱ tongue squamous cell carcinoma, while S+R and S+R+C are better treatment modalities for stage Ⅲ—IV disease;however, advanced patients have a poor prognosis after being treated with R and C+R modalities.
Wang Boqing,Liu Pan,Zhao Huarong et al. Outcomes of tongue squamous cell carcinoma treated with different treatment modalities[J]. Chinese Journal of Radiation Oncology, 2014, 23(3): 244-247.
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