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射波刀治疗48例肺转移瘤的疗效和预后分析
曲晨慧, 刘宁波, 庄洪卿, 宋勇春, 董洋, 巩琳琳, 袁智勇
300060 天津市肿瘤防治重点实验室天津医科大学附属肿瘤医院放疗科
Results and prognostic factors of CyberKnife for lung metastasis
QU Chen-hui, LIU Ning-bo, ZHUANG Hong-qing, SONG Yong-chun, DONG Yang, GONG Lin-lin, YUAN Zhi-yong
Department of Radiotherapy, Cancer Hospital of Tianjin Medical University;Tianjin Key laboratory of Tumor Research and Control;Tianjin 300060, China Corresponding author:YUAN Zhi-yong, Email:zhiyong0524@163.com
Abstract：Objective To investigate the effectiveness and toxicity of CyberKnife in the treatment of lung metastases. Methods Treatment details and outcomes were reviewed for 93 targets of 48 histologically verified patients treated by CyberKnife at the CyberKnife Center of Tianjin between September 2006 and June 2010. The median tumor volume was 6.0(0.2－135.2) cm3, the median biological equivalent dose was 140.8(53－180) cGy (α/β=10),the median fraction was 3(1－7) times and the median isodose line was 81%(71%－91%). Results The rate of follow-up is 96%. 33 cases were followed up for more than 2 years. The effective rate was 90.3%.Two targets of 2 patients locally progressed. The 1-and 2-year local control rates, overall survival (OS) rates and progression-free survival (PFS) rates were 98% and 98%, 83% and 63%,and 64% and 37%, respectively. Univariate analyses showed that age older than 60 versus ≤60 years tended to be predictor for PFS (χ2=3.45,P=0.063);The PFS of patients who had single lesion was better than patients with multiple lesions (χ2=4.49,P=0.034);patients with disease-free interval longer than 18 months had better OS (χ2=6.50,P=0.011).Five patients were reported to experience treatment-related grade 1 radiation pulmonary injury, and one each for subcutaneous fibrosis with pigmentation, grade 2 and grade 3 adverse event. Conclusions For patients with lung metastatic lesion, CyberKnife is an effective option with high local control rate and little acute reaction. The long-term outcome and toxicity need further study.
QU Chen-hui,LIU Ning-bo,ZHUANG Hong-qing et al. Results and prognostic factors of CyberKnife for lung metastasis[J]. Chinese Journal of Radiation Oncology, 2012, 21(3): 214-216.
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2012, Vol. 21 
