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直肠内气囊对前列腺癌调强放疗中危及器官的剂量学影响
王文卿, 王维虎, 李晔雄, 金晶, 刘跃平, 王淑莲, 宋永文, 徐英杰, 戴建荣
100021 北京,中国医学科学院北京协和医学院肿瘤医院肿瘤研究所放疗科
The influence of endorectal balloon on normal tissue dosimetry in prostate cancer treated with intensity-modulated radiation therapy
WANG Wen-qing,WANG Wei-hu,LI Ye-xiong,JIN Jing,LIU Yue-ping, WANG Shu-lian,SONG Yong-wen, XU Ying-jie, DAI Jian-rong
Department of Radiation Oncology, Cancer Hospital (Institute),Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021,China
Corresponding author:LI Ye-xiong,Email:yexiong@yahoo.com
Objective To investigate the influence of endorectal balloon on normal tissue dosimetry in prostate cancer patients treated with intensity-modulated radiation therapy (IMRT). Methods Ten patients with prostate cancer were included and each had two sets of planning CT-scans:one with and one without an air-filled endorectal balloon. Target volumes and organs at risk (rectum,bladder,femoral heads) were contoured on the 20 CT scans and IMRT plannings were performed. The prescription dose was 78 Gy to 95% of planning target volume. The percentage of volume of organs at risk (without or with endorectal balloon) receiving more than 10 Gy, 20 Gy, 30 Gy, 40 Gy, 50 Gy, 60 Gy, 70 Gy and 75 Gy (V10－V70, in increments of 10 Gy, and V75) were analyzed. Results The V10－V60 of rectum with endorectal balloon were 75.5%, 52.6%, 35.3%, 26.1%, 19.6%, 14.2%,and those without endorectal balloon were 82.2%, 62.8%, 43.9%, 31.4%, 24.0%, 17.1%, respectively (χ2=9.46,P<0.01).Use of endorectal balloon significantly reduced the dose to the rectum (V10－V60). The V70 and V75 of rectum with endorectal balloon were 9.1% and 8.2%;and those without endorectal balloon were 9.9% and 6.2% respectively (χ2=1.82,P>0.05).The difference was not significant. There were nosignificant differences in the dose tobladder,left and right femoral head between patients with and without endorectal balloon. Conclusions Endorectal balloon can significantly decrease the medium and low dose volume of rectum for prostate cancer patients treated with IMRT, which may reduce the rectal toxicity.
WANG Wen-qing,WANG Wei-hu,LI Ye-xiong et al. The influence of endorectal balloon on normal tissue dosimetry in prostate cancer treated with intensity-modulated radiation therapy[J]. Chinese Journal of Radiation Oncology, 2012, 21(2): 156-159.
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2012, Vol. 21 
