Research progress on the oxygen depletion hypothesis of ultra-high dose rate radiotherapy
Zhu Hongyu1, Zhang Qixian2, Deng Xiaowu1
1Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou 510060, China; 2Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200030, China
Abstract：In recent years, ultra-high dose rate (FLASH) radiotherapy has become one of the most advanced research topics in the field of radiotherapy. Experimental data indicate that FLASH radiotherapy can significantly reduce the irradiation damage in normal tissues while being as effective as clinical conventional dose rate radiotherapy in tumor control. The oxygen depletion hypothesis is considered as one of the key mechanisms underlying the FLASH effect. In this article, research progress on the discovery, experimental evidence and reaction principle of oxygen depletion was reviewed, the measurement methods and biological effect modeling methods of the oxygen depletion hypothesis were summarized, and the oxygen depletion difference between normal tissue and tumor was also discussed.
Zhu Hongyu,Zhang Qixian,Deng Xiaowu. Research progress on the oxygen depletion hypothesis of ultra-high dose rate radiotherapy[J]. Chinese Journal of Radiation Oncology, 2023, 32(4): 379-383.
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