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不同诱导化疗疗效对非高发区局部晚期鼻咽癌调强放疗同期化疗预后影响
孙学明, 卢晓旭, 黄蓉, 吴慧
郑州大学附属肿瘤医院 河南省肿瘤医院放疗科 450008
Effect of different induction chemotherapy on clinical prognosis of patients with non-endemic locally-advanced nasopharyngeal carcinoma after concurrent chemotherapy with IMRT
Sun Xueming, Lu Xiaoxu, Huang Rong, Wu Hui
Department of Radiation Oncology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China
Abstract：Objective To evaluate effect of different induction chemotherapy on the clinical efficacy of concurrent intensity-modulated radiotherapy (IMRT) and chemotherapy and identify the prognostic factors in non-endemic locally-advanced nasopharyngeal carcinoma patients. Methods Clinical data of 210 patients with stage Ⅲ-ⅣB(excluding stage T3-4N0M0) nasopharyngeal carcinoma treated in our hospital from 2012 to 2017 were retrospectively analyzed. According to the efficacy of different induction chemotherapy, all patients were divided into the effective group (14 cases of complete remission and 165 cases of partial remission) and ineffective group (31 cases of stability and 0 case of progression). Survival analysis was performed by Kaplan-Meier method. Multivariate analysis was conducted by using Cox′s regression model. Results Compared with the ineffective group, the 3-year overall survival (OS)(89.2% vs. 74.2%, P=0.005), recurrence-free survival (RFS)(93.0% vs. 81.9%, P=0.010) and progression-free survival (PFS)(80.2% vs. 58.1%, P=0.005) were significantly higher in the effective group, whereas the distant metastasis-free survival did not significantly differ between two groups (84.1% vs.69.7%, P=0.070). Multivariate analysis showed that the tumor response to induction chemotherapy was an independent prognostic factor for OS, RFS and PFS. Conclusions Tumor response to induction chemotherapy might be a prognostic factor for non-endemic locally-advanced nasopharyngeal carcinoma patients. Clinical prognosis of patients with poor response to induction chemotherapy is even worse. More intensive treatment and closer follow-up may be needed for these patients.
Sun Xueming,Lu Xiaoxu,Huang Rong et al. Effect of different induction chemotherapy on clinical prognosis of patients with non-endemic locally-advanced nasopharyngeal carcinoma after concurrent chemotherapy with IMRT[J]. Chinese Journal of Radiation Oncology, 2021, 30(5): 434-439.
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