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微生物群在放疗诱导损伤中的作用研究进展
刘景丽1, 李兰1, 周鹏程2, 杨娟1, 李向荣1, 瞿广桥1
1武汉科技大学附属孝感医院肿瘤科 432000; 2郑州大学第一附属医院放疗科 450052
Research progress on the role of microbiota in radiotherapy-induced injury
Liu Jingli1, Li Lan1, Zhou Pengcheng2, Yang Juan1, Li Xiangrong1, Qu Guangqiao1
1Department of Oncology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, China; 2Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Abstract：Human microbiota is composed of bacteria, viruses, fungi and other microorganisms, which are distributed in the oral cavity, nasal cavity, intestine, vagina and skin, etc. Human microbiota plays a pivotal role in the metabolism, immunity, hormones and homeostasis of the host. It can protect the host and maintain the homeostasis, and provoke the incidence of inflammation and tumors. Microbiota has been found to modulate the efficacy and toxicity of chemotherapy and immunotherapy for certain types of tumors. Nevertheless, large-scale studies in the context of radiation therapy have not been performed. In this article, the relationship between the microbiota and the radiotherapy response and toxicity changes of cancer patients was summarized, aiming to develop the optimal treatment plan for patients, and provide evidence for the prevention and treatment of radiotherapy-induced injury.
Liu Jingli,Li Lan,Zhou Pengcheng et al. Research progress on the role of microbiota in radiotherapy-induced injury[J]. Chinese Journal of Radiation Oncology, 2021, 30(5): 531-534.
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